Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5321961 | 0.89 | CSF1R (0.46) | CSF1RMAPTPDE4BJAK2JAK1 | |
| SCHEMBL5318638 | 0.87 | PDE4B (0.48) | CSF1RMAPTPDE4BPDE4APDE4C | |
| SCHEMBL5960601 | 0.87 | PDE4B (0.56) | CSF1RPDE4BJAK2JAK1 | |
| SCHEMBL2479148 | 0.76 | PDE4B (0.58) | CSF1RPDE4B | |
| SCHEMBL5318637 | 0.76 | PDE4B (0.50) | CSF1RPDE4BJAK2JAK1TP53 | |
| Hydrogen Sulfide SCHEMBL2479876 | 0.73 | PDE4B (0.38) | CSF1RPDE4BPDE4APDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL5319170 | 0.72 | CSF1R (0.57) | CSF1RMAPTPDE4BEGFR | |
| SCHEMBL5319139 | 0.72 | PDE4B (0.51) | CSF1RMAPTPDE4BPDE4APDE4C | |
| SCHEMBL5320584 | 0.71 | PDE4B (0.53) | CSF1RMAPTPDE4BPDE4APDE4C | |
| SCHEMBL5322799 | 0.70 | PDE4B (0.55) | CSF1RMAPTPDE4BPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007107499-A1 | QUINOLINE DERIVATIVES USEFUL AS PDE4 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-09-27 | — | — | WO | disclosed |