Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 7/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5323442 | 0.86 | DHFR (0.58) | DHFR | |
| SCHEMBL15056149 | 0.83 | DHFR (0.82) | DHFR | |
| SCHEMBL15056153 | 0.83 | DHFR (0.82) | DHFR | |
| SCHEMBL8444708 | 0.79 | DHFR (0.49) | DHFR | |
| SCHEMBL24344803 | 0.79 | DHFR (0.52) | DHFR | |
| SCHEMBL7253914 | 0.78 | DHFR (0.47) | DHFR | |
| SCHEMBL20286623 | 0.78 | DHFR (0.72) | DHFR | |
| SCHEMBL8420248 | 0.77 | DHFR (0.47) | DHFR | |
| SCHEMBL19918327 | 0.76 | DHFR (0.76) | DHFR | |
| SCHEMBL16546067 | 0.76 | DHFR (0.76) | DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007098089-A2 | TREATMENT OF HYPERPROLIFERATIVE DISEASES WITH METHOTREXATE N-OXIDE AND ANALOGS | NOVACEA, INC. (US) | 2007-08-30 | — | — | WO | claimed |