Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL532301 | 1.00 | MEN1 (0.47) | MEN1KMT2ATRPM8NR1I2HPGD | |
| SCHEMBL1529186 | 0.81 | CYP3A4 (0.47) | MEN1KMT2ATRPM8HPGDGAA | |
| SCHEMBL1529187 | 0.81 | CYP3A4 (0.47) | MEN1KMT2ATRPM8HPGDGAA | |
| SCHEMBL531673 | 0.79 | MEN1 (0.48) | MEN1KMT2AHPGDGAAALDH1A1 | |
| SCHEMBL531674 | 0.79 | MEN1 (0.48) | MEN1KMT2AHPGDGAAALDH1A1 | |
| SCHEMBL15670729 | 0.77 | KMT2A (0.59) | MEN1KMT2AHPGDALDH1A1LMNA | |
| SCHEMBL15670960 | 0.77 | KMT2A (0.59) | MEN1KMT2AHPGDALDH1A1LMNA | |
| SCHEMBL1529072 | 0.76 | CASR (0.49) | TRPM8ALDH1A1L3MBTL1 | |
| SCHEMBL1529070 | 0.76 | CASR (0.49) | TRPM8ALDH1A1L3MBTL1 | |
| SCHEMBL531228 | 0.76 | MEN1 (0.48) | MEN1KMT2ATRPM8NR1I2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2415759-A1 | CETP inhibitors | Merck Sharp & Dohme Corporation (US) | 2012-02-08 | — | — | EP | disclosed |