Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.41 |
| ▸ | MMP1 | P03956 | 2/20 | 0.40 |
| ▸ | MMP3 | P08254 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17965952 | 0.85 | PGR (0.57) | MEN1KMT2APGRADRA2AADRA2B | |
| SCHEMBL1506535 | 0.82 | TACR1 (0.48) | MEN1KMT2ATRPM8 | |
| SCHEMBL531388 | 0.78 | KMT2A (0.49) | MEN1KMT2APGRADRA2AADRA2B | |
| SCHEMBL532486 | 0.78 | KMT2A (0.49) | MEN1KMT2APGRADRA2AADRA2B | |
| SCHEMBL19349131 | 0.76 | MEN1 (0.61) | MEN1KMT2AMMP1MMP3ALDH1A1 | |
| SCHEMBL532302 | 0.76 | MEN1 (0.47) | MEN1KMT2ASCN5ASCN9ATRPM8 | |
| SCHEMBL532301 | 0.76 | MEN1 (0.47) | MEN1KMT2ASCN5ASCN9ATRPM8 | |
| SCHEMBL15812249 | 0.75 | KMT2A (0.59) | MEN1KMT2AMMP1MMP3ALDH1A1 | |
| SCHEMBL15670744 | 0.75 | KMT2A (0.59) | MEN1KMT2AMMP1MMP3ALDH1A1 | |
| SCHEMBL5163796 | 0.73 | CES2 (0.50) | MEN1KMT2AADRA2BTRPM8SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2415759-A1 | CETP inhibitors | Merck Sharp & Dohme Corporation (US) | 2012-02-08 | — | — | EP | disclosed |