Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | DAGLA | Q9Y4D2 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | CASP1 | P29466 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL737475 | 0.80 | NPSR1 (0.40) | MEN1KMT2ADAGLAATMALDH1A1 | |
| SCHEMBL532611 | 0.79 | NPSR1 (0.37) | MEN1KMT2ADAGLAATMALDH1A1 | |
| SCHEMBL531391 | 0.78 | MEN1 (0.43) | MEN1KMT2ADAGLAATMHPGD | |
| SCHEMBL7086962 | 0.74 | PRSS1 (0.39) | MEN1KMT2A | |
| SCHEMBL15670729 | 0.73 | KMT2A (0.59) | MEN1KMT2AATMHPGDALDH1A1 | |
| SCHEMBL15670960 | 0.73 | KMT2A (0.59) | MEN1KMT2AATMHPGDALDH1A1 | |
| SCHEMBL7361684 | 0.72 | CSNK1E (0.40) | ALDH1A1SMN1; SMN2HSD17B10MAPK1CASP1 | |
| SCHEMBL531674 | 0.72 | MEN1 (0.48) | MEN1KMT2AHPGDALDH1A1POLB | |
| SCHEMBL531673 | 0.72 | MEN1 (0.48) | MEN1KMT2AHPGDALDH1A1POLB | |
| SCHEMBL10242206 | 0.71 | ATM (0.54) | ATMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2415759-A1 | CETP inhibitors | Merck Sharp & Dohme Corporation (US) | 2012-02-08 | — | — | EP | disclosed |