SCHEMBL5323922

SCHEMBL5323922

CCNC(=O)c1noc(-c2cc(Cl)c(O)cc2O)c1-c1ccc(OCCF)cc1

nearest known ligand 0.81

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 5/20 0.81
HDAC4 P56524 5/20 0.81
HDAC1 Q13547 5/20 0.81
HDAC7 Q8WUI4 5/20 0.81
HDAC2 Q92769 5/20 0.81
HDAC10 Q969S8 5/20 0.81
HDAC11 Q96DB2 5/20 0.81
HDAC8 Q9BY41 5/20 0.81
HDAC6 Q9UBN7 5/20 0.81
HDAC9 Q9UKV0 5/20 0.81
HDAC5 Q9UQL6 5/20 0.81
HSP90AA1 P07900 14/20 0.78
HSP90AB1 P08238 14/20 0.78
PDK1 Q15118 3/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5321392 0.91 HDAC3 (0.67) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL4249723 0.90 HDAC3 (1.00) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL3960023 0.89 HDAC3 (1.00) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL4252830 0.89 HDAC3 (0.80) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL11994506 0.89 HDAC3 (0.75) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL3962972 0.88 HDAC3 (1.00) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL3956599 0.88 HDAC3 (1.00) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL3959029 0.88 HDAC3 (0.81) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL2948052 0.88 HSP90AB1 (1.00) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL29370045 0.88 HSP90AB1 (1.00) HDAC3HDAC4HDAC1HDAC7HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007096194-A1 RADIO-LABELED ISOXAZOLE DERIVATIVES USEFUL FOR THE LABELING AND DIAGNOSTIC OF HSP90 FUNCTIONALITY NOVARTIS AG (CH) 2007-08-30 WO disclosed