Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.57 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31301242 | 0.93 | DRD2 (0.63) | DRD2CACNA1HTDP1SIGMAR1MEN1 | |
| SCHEMBL30380480 | 0.91 | TDP1 (0.59) | DRD2CACNA1HTDP1SIGMAR1MEN1 | |
| SCHEMBL13202614 | 0.89 | DRD2 (0.59) | DRD2CACNA1HTDP1SIGMAR1MEN1 | |
| SCHEMBL18390128 | 0.87 | DRD2 (0.57) | DRD2CACNA1HTDP1SIGMAR1MEN1 | |
| SCHEMBL24172673 | 0.87 | DRD2 (0.56) | DRD2CACNA1HTDP1SIGMAR1MEN1 | |
| SCHEMBL4024516 | 0.87 | DRD2 (0.56) | DRD2CACNA1HTDP1MEN1GAA | |
| SCHEMBL31301250 | 0.87 | DRD2 (0.56) | DRD2CACNA1HTDP1SIGMAR1MEN1 | |
| SCHEMBL13075277 | 0.86 | DRD2 (0.56) | DRD2CACNA1HTDP1SIGMAR1MEN1 | |
| SCHEMBL31496727 | 0.86 | DRD2 (0.56) | DRD2CACNA1HTDP1SIGMAR1MEN1 | |
| SCHEMBL485945 | 0.85 | DRD2 (0.55) | DRD2CACNA1HTDP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114341128-B | Bifunctional protein degradation targeting chimeric compound, preparation method and medical application thereof | 恩瑞生物医药科技（上海）有限公司 | 2024-06-25 | — | — | CN | disclosed |
| CN-114341128-A | Bifunctional protein degradation targeting chimera compound and preparation method and medical application thereof | 恩瑞生物医药科技（上海）有限公司 | 2022-04-12 | — | — | CN | disclosed |
| WO-2022017442-A1 | BIFUNCTIONAL PROTEIN DEGRADATION-TARGETED CHIMERA COMPOUND, PREPARATION METHOD THEREFOR AND MEDICINAL USE THEREOF | 恩瑞生物医药科技（上海）有限公司 | 2022-01-27 | — | — | WO | disclosed |
| WO-2007102679-A1 | NOVEL THIENOPYRIMIDINE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | JE IL PHARMACEUTICAL CO., LTD. (KR) | 2007-09-13 | — | — | WO | disclosed |