SCHEMBL5324322

SCHEMBL5324322

C#CC(N)CCc1ccc(C)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.47
CYP2A6 P11509 1/20 0.47
TAAR1 Q96RJ0 1/20 0.47
PYCR1 P32322 1/20 0.38
AGXT P21549 2/20 0.36
MAOB P27338 1/20 0.36
DPP4 P27487 1/20 0.36
IDO1 P14902 1/20 0.35
HRH3 Q9Y5N1 1/20 0.35
KCNH2 Q12809 1/20 0.35
FFAR1 O14842 1/20 0.35
METAP2 P50579 1/20 0.35
METAP1 P53582 1/20 0.35
CYP2D6 P10635 1/20 0.34
NFKB1 P19838 1/20 0.34
LMNA P02545 1/20 0.34
MAPT P10636 1/20 0.34
IGF1R P08069 1/20 0.34
ALOX15 P16050 1/20 0.34
ALDH1A1 P00352 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10296151 0.89 CYP1A2 (0.44) CYP1A2CYP2A6TAAR1PYCR1AGXT
SCHEMBL28174584 0.81 CYP1A2 (0.47) CYP1A2CYP2A6TAAR1AGXTDPP4
SCHEMBL24098427 0.80 TAAR1 (0.40) CYP1A2CYP2A6TAAR1PYCR1AGXT
SCHEMBL10348476 0.80 ANPEP (0.47) CYP2A6TAAR1MAOBCYP2D6NFKB1
SCHEMBL15142215 0.77 CYP1A2 (0.42) CYP1A2CYP2A6TAAR1PYCR1MAOB
SCHEMBL9386674 0.75 TAAR1 (0.54) CYP1A2CYP2A6TAAR1AGXTMAOB
SCHEMBL5445176 0.74 CYP1A2 (0.52) CYP1A2CYP2A6TAAR1AGXTDPP4
SCHEMBL8608053 0.72 CYP1A2 (0.56) CYP1A2CYP2A6TAAR1AGXTDPP4
SCHEMBL1274308 0.70 CALM1 (0.49) CYP1A2TAAR1PYCR1AGXTMAOB
SCHEMBL10296057 0.70 IGF1R (0.43) CYP1A2CYP2A6TAAR1PYCR1MAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1773853-A1 MONOPHOSPHINE COMPOUNDS, TRANSITION METAL COMPLEXES THEREOF AND PRODUCTION OF OPTICALLY ACTIVE COMPOUNDS USING THE COMPLEXES AS ASYMMETRIC CATALYSTS Sumitomo Chemical Company, Limited (JP) 2007-04-18 EP disclosed
WO-2005121157-A1 MONOPHOSPHINE COMPOUNDS, TRANSITION METAL COMPLEXES THEREOF AND PRODUCTION OF OPTICALLY ACTIVE COMPOUNDS USING THE COMPLEXES AS ASYMMETRIC CATALYSTS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2005-12-22 WO disclosed