Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.97 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.53 |
| ▸ | NCF1 | P14598 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL233710 | 0.98 | EPHX2 (1.00) | EPHX2HSD11B1GAAMAPTTSHR | |
| Hydrochloric Acid SCHEMBL10319192 | 0.97 | EPHX2 (0.97) | EPHX2HSD11B1GAAMAPTTSHR | |
| SCHEMBL5356587 | 0.93 | EPHX2 (0.89) | EPHX2HSD11B1GAAMAPTTSHR | |
| SCHEMBL22668886 | 0.83 | EPHX2 (0.73) | EPHX2HSD11B1GAAMAPTTSHR | |
| SCHEMBL22669112 | 0.82 | EPHX2 (0.71) | EPHX2HSD11B1GAAMAPTTSHR | |
| SCHEMBL1366662 | 0.81 | EPHX2 (0.69) | EPHX2HSD11B1GAAMAPTTSHR | |
| SCHEMBL2420277 | 0.80 | EPHX2 (0.68) | EPHX2HSD11B1GAAMAPTTSHR | |
| SCHEMBL1375425 | 0.79 | EPHX2 (0.68) | EPHX2HSD11B1GAAMAPTTSHR | |
| SCHEMBL1375423 | 0.79 | EPHX2 (0.68) | EPHX2HSD11B1GAAMAPTTSHR | |
| SCHEMBL30582915 | 0.79 | EPHX2 (0.68) | EPHX2HSD11B1GAAMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007135427-A1 | 1,4-DISUBSTITUTED PIPERAZINE AND 1,4-DISUBSTITUTED AZEPANE AS 11 -BETA-HYDROXYSTEROID DEHYDROGENASE 1 INHIBITORS | ASTRAZENECA AB (SE) | 2007-11-29 | — | — | WO | disclosed |