Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 17/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5348156 | 0.92 | HRH3 (0.57) | HRH3MAOBKCNH2 | |
| SCHEMBL5339292 | 0.92 | HRH3 (0.57) | HRH3MAOBKCNH2 | |
| SCHEMBL5320367 | 0.92 | HRH3 (0.57) | HRH3MAOBKCNH2 | |
| SCHEMBL5318727 | 0.86 | HRH3 (0.56) | HRH3MAOBSLC6A4 | |
| SCHEMBL5324899 | 0.86 | HRH3 (0.62) | HRH3MAOBSLC6A4KCNH2 | |
| SCHEMBL5327795 | 0.86 | HRH3 (0.62) | HRH3MAOBSLC6A4KCNH2 | |
| SCHEMBL5366527 | 0.85 | HRH3 (0.54) | HRH3MAOBSLC6A4 | |
| SCHEMBL5319850 | 0.85 | HRH3 (0.50) | HRH3MAOBKCNH2 | |
| SCHEMBL5416020 | 0.85 | HRH3 (0.48) | HRH3MAOBSLC6A4 | |
| SCHEMBL5319682 | 0.84 | HRH3 (0.54) | HRH3MAOBSLC6A4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007099423-A1 | 1-PYRROLIDINE INDANE DERIVATIVES AS HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2007-09-07 | — | — | WO | claimed |
| WO-2007099423-A1 | 1-PYRROLIDINE INDANE DERIVATIVES AS HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2007-09-07 | — | — | WO | disclosed |