Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 15/20 | 0.57 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | HRH1 | P35367 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5339292 | 1.00 | HRH3 (0.57) | HRH3MAOBKCNH2HRH1 | |
| SCHEMBL5320367 | 1.00 | HRH3 (0.57) | HRH3MAOBKCNH2HRH1 | |
| SCHEMBL5327795 | 0.94 | HRH3 (0.62) | HRH3MAOBKCNH2HRH1 | |
| SCHEMBL5324899 | 0.94 | HRH3 (0.62) | HRH3MAOBKCNH2HRH1 | |
| SCHEMBL5318727 | 0.94 | HRH3 (0.56) | HRH3MAOB | |
| SCHEMBL5366527 | 0.93 | HRH3 (0.54) | HRH3MAOB | |
| SCHEMBL5319682 | 0.92 | HRH3 (0.54) | HRH3MAOBKCNH2 | |
| SCHEMBL5325115 | 0.92 | HRH3 (0.49) | HRH3MAOBKCNH2 | |
| SCHEMBL5326281 | 0.90 | HRH3 (0.57) | HRH3MAOBHRH1 | |
| SCHEMBL5416020 | 0.90 | HRH3 (0.48) | HRH3MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007099423-A1 | 1-PYRROLIDINE INDANE DERIVATIVES AS HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2007-09-07 | — | — | WO | disclosed |
| WO-2007099423-A1 | 1-PYRROLIDINE INDANE DERIVATIVES AS HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2007-09-07 | — | — | WO | disclosed |