SCHEMBL5325355

SCHEMBL5325355

COC(=O)c1ccc(OC(F)(F)C(F)(F)Br)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 2/20 0.56
CA2 P00918 2/20 0.56
MAPT P10636 4/20 0.51
TDP1 Q9NUW8 1/20 0.48
CA12 O43570 1/20 0.48
CA7 P43166 1/20 0.48
CA9 Q16790 1/20 0.48
CA14 Q9ULX7 1/20 0.48
NOTUM Q6P988 2/20 0.47
STS P08842 1/20 0.47
LMNA P02545 1/20 0.47
KMT2A Q03164 2/20 0.46
RAB9A P51151 2/20 0.46
KDM4E B2RXH2 1/20 0.46
MEN1 O00255 1/20 0.46
MRGPRX4 Q96LA9 1/20 0.46
TSHR P16473 1/20 0.46
ALDH1A1 P00352 2/20 0.45
FAAH O00519 1/20 0.44
EPHX2 P34913 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL514352 0.85 CA1 (0.64) CA1CA2MAPTTDP1CA12
SCHEMBL9141744 0.83 CA1 (0.53) CA1CA2MAPTTDP1CA12
SCHEMBL6854223 0.83 NOTUM (0.49) CA1CA2MAPTTDP1CA12
SCHEMBL934140 0.82 CA1 (0.60) CA1CA2MAPTTDP1CA12
SCHEMBL28050325 0.82 CA1 (0.60) CA1CA2MAPTTDP1CA12
SCHEMBL9006596 0.82 MAPT (0.53) MAPTSTSLMNAKMT2ARAB9A
SCHEMBL5312032 0.82 PPARG (0.45) MAPTTDP1STSLMNAKMT2A
SCHEMBL5328114 0.81 MRGPRX4 (0.51) NOTUMKMT2ARAB9AMEN1MRGPRX4
SCHEMBL14930553 0.81 CA1 (0.58) CA1CA2MAPTTDP1CA12
SCHEMBL9173852 0.80 PARP10 (0.55) CA1CA2KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007114652-A1 NOVEL BENZIMIDAZOLE MONOMERS TERMINATED WITH TRIFLUOROVINYLOXY GROUPS AND POLYBENZIMIDAZOLES MEMBRANE PREPARED BY USING THE SAME MONOMERS KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2007-10-11 WO disclosed
EP-0428709-B1 REACTIVE COMPOUNDS CONTAINING PERFLUOROVINYL GROUPS DOW CHEMICAL CO (US) 1995-05-24 EP disclosed
EP-0476560-B1 Polybenzazole polymers containing perfluorocyclobutane rings DOW CHEMICAL CO (US) 1995-05-17 EP disclosed
EP-0368006-B1 Copolymers containing polybenzoxazole polybenzothiazole and polybenzimidazole moieties DOW CHEMICAL CO (US) 1995-04-05 EP disclosed
US-5364917-A Perfluorocyclobutane ring-containing polymers THE DOW CHEMICAL COMPANY (US) 1994-11-15 US disclosed
EP-0428708-B1 PROCESS FOR PREPARING A POLYMER HAVING PERFLUOROCYCLOBUTANE RINGS AND POLYMERS CONTAINING PERFLUOROCYCLOBUTANE RINGS DOW CHEMICAL CO (US) 1994-10-05 EP disclosed
EP-0428706-B1 PERFLUOROVINYL COMPOUNDS DOW CHEMICAL CO (US) 1994-07-13 EP disclosed
US-5225515-A Poly(aryl ether) polymers containing perfluorocyclobutane rings THE DOW CHEMICAL COMPANY (US) 1993-07-06 US disclosed
US-5210265-A Multistage reaction to form monomers for polymers such as polyesters by dimerization of trifluorovinyl compounds by dehalogenation and cyclization THE DOW CHEMICAL COMPANY (US) 1993-05-11 US disclosed
US-5198513-A Compounds for engineering thermoplastics or dimers THE DOW CHEMICAL COMPANY (US) 1993-03-30 US disclosed
EP-0428708-A1 PROCESS FOR PREPARING A POLYMER HAVING PERFLUOROCYCLOBUTANE RINGS AND POLYMERS CONTAINING PERFLUOROCYCLOBUTANE RINGS. DOW CHEMICAL CO (US) 1991-05-29 EP disclosed
EP-0428709-A1 REACTIVE COMPOUNDS CONTAINING PERFLUOROVINYL GROUPS. DOW CHEMICAL CO (US) 1991-05-29 EP disclosed
EP-0428706-A1 PERFLUOROVINYL COMPOUNDS. DOW CHEMICAL CO (US) 1991-05-29 EP disclosed
WO-1990015042-A2 REACTIVE COMPOUNDS CONTAINING PERFLUOROVINYL GROUPS THE DOW CHEMICAL COMPANY (US) 1990-12-13 WO disclosed
WO-1990015043-A2 PERFLUOROVINYL COMPOUNDS THE DOW CHEMICAL COMPANY (US) 1990-12-13 WO disclosed
WO-1990015044-A2 REACTIVE COMPOUNDS CONTAINING PERFLUOROCYCLOBUTANE RINGS THE DOW CHEMICAL COMPANY (US) 1990-12-13 WO disclosed
WO-1990015082-A1 PROCESS FOR PREPARING A POLYMER HAVING PERFLUOROCYCLOBUTANE RINGS AND POLYMERS CONTAINING PERFLUOROCYCLOBUTANE RINGS THE DOW CHEMICAL COMPANY (US) 1990-12-13 WO disclosed
EP-0392008-A1 COPOLYMERS CONTAINING POLYBENZOXAZOLE, POLYBENZOTHIAZOLE AND POLYBENZIMIDAZOLE MOIETIES THE DOW CHEMICAL COMPANY (US) 1990-10-17 EP disclosed
EP-0368006-A2 Copolymers containing polybenzoxazole polybenzothiazole and polybenzimidazole moieties THE DOW CHEMICAL COMPANY (US) 1990-05-16 EP disclosed
WO-1990003995-A1 COPOLYMERS CONTAINING POLYBENZOXAZOLE, POLYBENZOTHIAZOLE AND POLYBENZIMIDAZOLE MOIETIES THE DOW CHEMICAL COMPANY (US) 1990-04-19 WO disclosed