Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | THRA | P10827 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4640545 | 0.85 | SMN1; SMN2 (0.55) | SMN1; SMN2PTGDR2MCL1PTPN7TSHR | |
| SCHEMBL4640556 | 0.82 | TSHR (0.56) | SMN1; SMN2PTGDR2MCL1PTPN7TSHR | |
| SCHEMBL4641630 | 0.81 | SMN1; SMN2 (0.50) | SMN1; SMN2PTGDR2MCL1PTPN7TSHR | |
| SCHEMBL22140242 | 0.80 | BACE1 (0.53) | SMN1; SMN2KDM4ETSHRMAPTHSD17B10 | |
| SCHEMBL4640614 | 0.80 | RXRA (0.53) | SMN1; SMN2PTGDR2KDM4EPTPN7PPARD | |
| SCHEMBL5321039 | 0.79 | MCL1 (0.62) | SMN1; SMN2PTGDR2KDM4EMCL1PTPN7 | |
| SCHEMBL4641530 | 0.79 | SMN1; SMN2 (0.48) | SMN1; SMN2PTGDR2MCL1PTPN7TSHR | |
| SCHEMBL3930793 | 0.78 | MCL1 (0.60) | SMN1; SMN2PTGDR2KDM4EMCL1PTPN7 | |
| SCHEMBL3923991 | 0.78 | SMN1; SMN2 (0.57) | SMN1; SMN2PTGDR2KDM4EMCL1PTPN7 | |
| SCHEMBL17896566 | 0.77 | SMN1; SMN2 (0.55) | SMN1; SMN2PTGDR2KDM4EMCL1PTPN7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007120012-A1 | NOVEL COMPOUNDS, ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST; AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | AMOREPACIFIC CORPORATION (KR) | 2007-10-25 | — | — | WO | disclosed |