Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.73 |
| ▸ | POLB | P06746 | 2/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | PDE4A | P27815 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.58 |
| ▸ | ACACB | O00763 | 1/20 | 0.58 |
| ▸ | CNR2 | P34972 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5320801 | 0.90 | ALDH1A1 (0.77) | ALDH1A1POLBSMN1; SMN2ACACBCNR2 | |
| SCHEMBL6297588 | 0.85 | ALDH1A1 (0.81) | ALDH1A1POLBCYP1A2SMN1; SMN2CNR2 | |
| SCHEMBL5330709 | 0.85 | ALDH1A1 (0.81) | ALDH1A1POLBSMN1; SMN2ACACBCNR2 | |
| SCHEMBL14399184 | 0.82 | ALDH1A1 (0.76) | ALDH1A1POLBCYP1A2SMN1; SMN2CNR2 | |
| SCHEMBL5325371 | 0.82 | ALDH1A1 (0.76) | ALDH1A1POLBCYP1A2KDM4ESMN1; SMN2 | |
| SCHEMBL5325429 | 0.82 | ALDH1A1 (0.76) | ALDH1A1POLBCYP1A2SMN1; SMN2CNR2 | |
| SCHEMBL14399186 | 0.81 | ALDH1A1 (0.74) | ALDH1A1POLBKDM4ECYP2D6SMN1; SMN2 | |
| SCHEMBL5327587 | 0.81 | ALDH1A1 (0.74) | ALDH1A1POLBCYP1A2SMN1; SMN2CNR2 | |
| SCHEMBL14399367 | 0.81 | ALDH1A1 (0.74) | ALDH1A1POLBCYP1A2SMN1; SMN2CNR2 | |
| SCHEMBL14399009 | 0.81 | ALDH1A1 (0.74) | ALDH1A1POLBCYP1A2KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007120083-A1 | THE USE OF CARBOXAMIDE DERIVATIVES IN THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF INFLAMMATORY, ALLERGIC AND DERMATOLOGICAL CONDITIONS | ASTRAZENECA AB (SE) | 2007-10-25 | — | — | WO | claimed |
| WO-2007120083-A1 | THE USE OF CARBOXAMIDE DERIVATIVES IN THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF INFLAMMATORY, ALLERGIC AND DERMATOLOGICAL CONDITIONS | ASTRAZENECA AB (SE) | 2007-10-25 | — | — | WO | disclosed |
| WO-2007120083-A1 | THE USE OF CARBOXAMIDE DERIVATIVES IN THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF INFLAMMATORY, ALLERGIC AND DERMATOLOGICAL CONDITIONS | ASTRAZENECA AB (SE) | 2007-10-25 | — | — | WO | disclosed |