Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | GBA1 | P04062 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5347507 | 0.86 | CHRM4 (0.61) | CHRM4TSHRALDH1A1KDM4EKMT2A | |
| SCHEMBL5331427 | 0.85 | CHRM4 (0.48) | PKMCHRM4TSHRALDH1A1TP53 | |
| SCHEMBL14386523 | 0.82 | CHRM4 (0.48) | CHRM4TSHRALDH1A1KDM4EPOLB | |
| SCHEMBL5329287 | 0.81 | MEN1 (0.60) | CHRM4TSHRALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL3210281 | 0.80 | CHRM4 (0.59) | CHRM4TSHRGBA1 | |
| SCHEMBL5351297 | 0.80 | KDM4E (0.59) | PKMCHRM4TSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL5349113 | 0.80 | KMT2A (0.61) | CHRM4TSHRALDH1A1KMT2ALMNA | |
| SCHEMBL16707660 | 0.79 | MEN1 (0.55) | PKMALDH1A1SMN1; SMN2KDM4EPOLB | |
| SCHEMBL5327466 | 0.79 | PKM (0.59) | PKMTSHRALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL5349081 | 0.78 | TSHR (0.55) | PKMTSHRALDH1A1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007122411-A1 | DIAZEPAN-1-YL-SULFONYL DERIVATIVES FOR THE TREATMENT OF METABOLIC SYNDROME | ASTRAZENECA AB (SE) | 2007-11-01 | — | — | WO | claimed |
| WO-2007122411-A1 | DIAZEPAN-1-YL-SULFONYL DERIVATIVES FOR THE TREATMENT OF METABOLIC SYNDROME | ASTRAZENECA AB (SE) | 2007-11-01 | — | — | WO | disclosed |
| WO-2007122411-A1 | DIAZEPAN-1-YL-SULFONYL DERIVATIVES FOR THE TREATMENT OF METABOLIC SYNDROME | ASTRAZENECA AB (SE) | 2007-11-01 | — | — | WO | disclosed |