Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.54 |
| ▸ | CNR2 | P34972 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29353444 | 0.78 | SMN1; SMN2 (0.77) | POLBSMN1; SMN2NOTUMNPSR1HTT | |
| SCHEMBL2829456 | 0.78 | SMN1; SMN2 (0.77) | POLBSMN1; SMN2NOTUMNPSR1HTT | |
| Hydrochloric Acid SCHEMBL11845665 | 0.77 | SMN1; SMN2 (0.74) | POLBSMN1; SMN2NOTUMNPSR1HTT | |
| SCHEMBL30592391 | 0.77 | SMN1; SMN2 (0.74) | POLBSMN1; SMN2NOTUMNPSR1HTT | |
| SCHEMBL330273 | 0.77 | SMN1; SMN2 (0.74) | POLBSMN1; SMN2NOTUMNPSR1HTT | |
| SCHEMBL10144052 | 0.77 | POLB (1.00) | POLBSMN1; SMN2NOTUMNPSR1HTT | |
| SCHEMBL4019697 | 0.76 | SMN1; SMN2 (0.79) | POLBSMN1; SMN2NOTUMNPSR1HTT | |
| SCHEMBL11326409 | 0.75 | SMN1; SMN2 (0.83) | POLBSMN1; SMN2NOTUMNPSR1HTT | |
| SCHEMBL8668250 | 0.75 | POLB (0.46) | POLBTDP1SMN1; SMN2NOTUMNPSR1 | |
| SCHEMBL4291340 | 0.75 | SMN1; SMN2 (0.77) | POLBSMN1; SMN2NOTUMNPSR1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007146230-A2 | NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | MERCK & CO., INC. (US) | 2007-12-21 | — | — | WO | disclosed |