Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 16/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 14/20 | 0.52 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14413752 | 0.88 | ADORA1 (0.54) | ADORA1ADORA2AADORA2BDYRK1AMAPT | |
| SCHEMBL14413008 | 0.77 | ADORA1 (0.53) | ADORA1ADORA2AADORA2BMAPTRXFP1 | |
| SCHEMBL14413002 | 0.75 | DYRK1A (0.51) | ADORA1ADORA2ADYRK1AKDM4ETDP1 | |
| SCHEMBL15298259 | 0.72 | KDM4E (0.58) | ADORA1ADORA2AMAPTRXFP1KDM4E | |
| SCHEMBL14413781 | 0.71 | ADORA1 (0.52) | ADORA1ADORA2AADORA2B | |
| SCHEMBL14413495 | 0.70 | RIPK2 (0.60) | ADORA1ADORA2ADYRK1AMAPT | |
| SCHEMBL27631638 | 0.69 | ADORA2A (0.53) | ADORA1ADORA2AKDM4E | |
| SCHEMBL27881810 | 0.68 | ADORA1 (0.62) | ADORA1ADORA2AADORA2B | |
| SCHEMBL14413324 | 0.68 | HSP90AA1 (0.62) | DYRK1AMAPTKDM4E | |
| SCHEMBL4905916 | 0.68 | ADORA1 (0.77) | ADORA1ADORA2AADORA2BMAPTRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007098835-A1 | AMINO PYRYMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2007-09-07 | — | — | WO | disclosed |
| WO-2007098835-A1 | AMINO PYRYMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2007-09-07 | — | — | WO | disclosed |