Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.36 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.36 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5327012 | 1.00 | KDM4E (0.47) | KDM4EALDH1A1GAAMAPK1HDAC3 | |
| SCHEMBL3541484 | 0.80 | NPC1 (0.53) | KDM4EALDH1A1GAAMAPK1HDAC3 | |
| SCHEMBL3541478 | 0.80 | NPC1 (0.53) | KDM4EALDH1A1GAAMAPK1HDAC3 | |
| SCHEMBL3543861 | 0.78 | HDAC8 (0.56) | KDM4EALDH1A1GAAMAPK1HDAC3 | |
| SCHEMBL3545133 | 0.77 | KDM4E (0.47) | KDM4EALDH1A1GAAMAPK1HDAC3 | |
| SCHEMBL3549948 | 0.76 | KDM4E (0.49) | KDM4EALDH1A1GAAMAPK1HDAC3 | |
| SCHEMBL3538211 | 0.76 | IDO1 (0.51) | KDM4EALDH1A1GAAMAPK1IDO1 | |
| SCHEMBL5327040 | 0.76 | ALDH1A1 (0.46) | KDM4EALDH1A1GAAMAPK1HDAC3 | |
| SCHEMBL3549945 | 0.76 | KDM4E (0.49) | KDM4EALDH1A1GAAMAPK1HDAC3 | |
| SCHEMBL3538215 | 0.76 | IDO1 (0.51) | KDM4EALDH1A1GAAMAPK1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833806-A1 | OXADIAZOLE DERIVATIVES AS DGAT INHIBITORS | AstraZeneca AB (SE) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006064189-A1 | OXADIAZOLE DERIVATIVES AS DGAT INHIBITORS | ASTRAZENECA AB (SE) | 2006-06-22 | — | — | WO | disclosed |