Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 9/20 | 0.44 |
| ▸ | KDR | P35968 | 4/20 | 0.44 |
| ▸ | TEK | Q02763 | 3/20 | 0.44 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2889266 | 0.88 | KDR (0.51) | RAF1KDRTEKEPHB4BRAF | |
| SCHEMBL2886220 | 0.79 | KDR (0.45) | RAF1KDRTEKEPHB4BRAF | |
| SCHEMBL5327725 | 0.78 | BRAF (0.45) | RAF1KDRTEKEPHB4BRAF | |
| SCHEMBL5959783 | 0.76 | KDR (0.51) | RAF1KDRTEKEPHB4BRAF | |
| SCHEMBL2889242 | 0.75 | EPHB4 (0.49) | KDRTEKEPHB4NR1H4KDM4E | |
| SCHEMBL4318407 | 0.74 | KDR (0.51) | RAF1KDRTEKEPHB4BRAF | |
| SCHEMBL5592761 | 0.74 | KMT2A (0.49) | EPHB4KDM4EMAPK1 | |
| SCHEMBL5593089 | 0.73 | EPHB4 (0.54) | RAF1KDRTEKEPHB4BRAF | |
| SCHEMBL2884845 | 0.73 | KDM4E (0.48) | KDRTEKEPHB4KDM4ESMN1; SMN2 | |
| SCHEMBL5959855 | 0.71 | KDR (0.45) | RAF1KDRTEKEPHB4BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007024294-A2 | CERTAIN SUBSTITUTED UREAS, AS MODULATORS OF KINASE ACTIVITY | CGI PHARMACEUTICALS, INC. (US) | 2007-03-01 | — | — | WO | claimed |