Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.45 |
| ▸ | TEK | Q02763 | 3/20 | 0.45 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.45 |
| ▸ | RAF1 | P04049 | 7/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MTTP | P55157 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2887786 | 0.87 | KDR (0.43) | KDRTEKEPHB4P2RX7KDM4E | |
| SCHEMBL2889266 | 0.87 | KDR (0.51) | KDRTEKEPHB4RAF1BRAF | |
| SCHEMBL5592491 | 0.86 | KDR (0.47) | KDRTEKEPHB4RAF1P2RX7 | |
| SCHEMBL2882897 | 0.79 | KDR (0.51) | KDREPHB4BRAF | |
| SCHEMBL5327733 | 0.79 | RAF1 (0.44) | KDRTEKEPHB4RAF1BRAF | |
| SCHEMBL5959841 | 0.79 | KDR (0.48) | KDRTEKEPHB4RAF1P2RX7 | |
| SCHEMBL5959783 | 0.78 | KDR (0.51) | KDRTEKEPHB4RAF1P2RX7 | |
| SCHEMBL5959880 | 0.78 | RAF1 (0.41) | KDRTEKEPHB4RAF1P2RX7 | |
| SCHEMBL2888120 | 0.77 | BRAF (0.53) | KDREPHB4BRAF | |
| SCHEMBL5592439 | 0.77 | KCNQ3 (0.57) | KDRTEKEPHB4RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8222421-B2 | Certain substituted ureas, as modulators of kinase activity | GILEAD CONNECTICUT, INC. (US) | 2012-07-17 | — | — | US | claimed |
| US-20100286190-A1 | CERTAIN SUBSTITUTED UREAS, AS MODULATORS OF KINASE ACTIVITY | CGI PHARMACEUTICALS, INC. | 2010-11-11 | — | — | US | claimed |
| WO-2007024294-A2 | CERTAIN SUBSTITUTED UREAS, AS MODULATORS OF KINASE ACTIVITY | CGI PHARMACEUTICALS, INC. (US) | 2007-03-01 | — | — | WO | claimed |
| US-20060270702-A1 | Certain substituted ureas, as modulators of kinase activity | GILEAD CONNECTICUT, INC. | 2006-11-30 | — | — | US | claimed |
| US-8222421-B2 | Certain substituted ureas, as modulators of kinase activity | GILEAD CONNECTICUT, INC. (US) | 2012-07-17 | — | — | US | disclosed |
| US-8222421-B2 | Certain substituted ureas, as modulators of kinase activity | GILEAD CONNECTICUT, INC. (US) | 2012-07-17 | — | — | US | disclosed |
| US-8222421-B2 | Certain substituted ureas, as modulators of kinase activity | GILEAD CONNECTICUT, INC. (US) | 2012-07-17 | — | — | US | disclosed |
| US-20100286190-A1 | CERTAIN SUBSTITUTED UREAS, AS MODULATORS OF KINASE ACTIVITY | CGI PHARMACEUTICALS, INC. | 2010-11-11 | — | — | US | disclosed |
| US-20100286190-A1 | CERTAIN SUBSTITUTED UREAS, AS MODULATORS OF KINASE ACTIVITY | CGI PHARMACEUTICALS, INC. | 2010-11-11 | — | — | US | disclosed |
| US-20100286190-A1 | CERTAIN SUBSTITUTED UREAS, AS MODULATORS OF KINASE ACTIVITY | CGI PHARMACEUTICALS, INC. | 2010-11-11 | — | — | US | disclosed |
| US-7777040-B2 | Certain substituted ureas, as modulators of kinase activity | CGI PHARMACEUTICALS, INC. (US) | 2010-08-17 | — | — | US | disclosed |
| US-7777040-B2 | Certain substituted ureas, as modulators of kinase activity | CGI PHARMACEUTICALS, INC. (US) | 2010-08-17 | — | — | US | disclosed |
| US-7777040-B2 | Certain substituted ureas, as modulators of kinase activity | CGI PHARMACEUTICALS, INC. (US) | 2010-08-17 | — | — | US | disclosed |
| US-20070202133-A1 | BENZIMIDAZOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION | SIRCAR JAGADISH C | 2007-08-30 | — | — | US | disclosed |
| EP-1368028-B1 | BENZIMIDAZOLE COMPOUNDS FOR MODULATING IGE AND INHIBITING CELLULAR PROLIFERATION | AVANIR PHARMACEUTICALS (US) | 2007-08-15 | — | — | EP | disclosed |
| WO-2007024294-A2 | CERTAIN SUBSTITUTED UREAS, AS MODULATORS OF KINASE ACTIVITY | CGI PHARMACEUTICALS, INC. (US) | 2007-03-01 | — | — | WO | disclosed |
| WO-2007024294-A2 | CERTAIN SUBSTITUTED UREAS, AS MODULATORS OF KINASE ACTIVITY | CGI PHARMACEUTICALS, INC. (US) | 2007-03-01 | — | — | WO | disclosed |
| US-20060270702-A1 | Certain substituted ureas, as modulators of kinase activity | GILEAD CONNECTICUT, INC. | 2006-11-30 | — | — | US | disclosed |
| EP-1368028-A1 | BENZIMIDAZOLE COMPOUNDS FOR MODULATING IGE AND INHIBITING CELLULAR PROLIFERATION | AVANIR PHARMACEUTICALS (US) | 2003-12-10 | — | — | EP | disclosed |
| WO-2002072090-A1 | BENZIMIDAZOLE COMPOUNDS FOR MODULATING IGE AND INHIBITING CELLULAR PROLIFERATION | AVANIR PHARMACEUTICALS (US) | 2002-09-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070202133-A1 | BENZIMIDAZOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION | MKI67, CMA1, CCNI | KDR 1406/4885TEK 2020/4885EPHB4 1529/4885 |
| US-20060270702-A1 | Certain substituted ureas, as modulators of kinase activity | UCK2, CHUK, TK1 | KDR 47/4885TEK 281/4885EPHB4 2792/4885 |
| US-20100286190-A1 | CERTAIN SUBSTITUTED UREAS, AS MODULATORS OF KINASE ACTIVITY | UCK2, CHUK, TK1 | KDR 47/4885TEK 281/4885EPHB4 2792/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.