Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 6/20 | 0.51 |
| ▸ | FYN | P06241 | 9/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | STAT6 | P42226 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2123416 | 0.92 | PIK3CA (0.58) | PIK3CAFYNMKNK1MKNK2KDM4E | |
| SCHEMBL2120454 | 0.87 | PIK3CA (0.64) | PIK3CAFYNKDM4EALDH1A1PKM | |
| SCHEMBL2123426 | 0.76 | KDM4E (0.44) | PIK3CAFYNMKNK1KDM4EALDH1A1 | |
| SCHEMBL532633 | 0.75 | PIK3CA (0.74) | PIK3CAFYNKDM4EALDH1A1PKM | |
| SCHEMBL532289 | 0.71 | PIK3CA (0.67) | PIK3CAFYNKDM4EALDH1A1PKM | |
| SCHEMBL2120460 | 0.69 | KDM4E (0.49) | PIK3CAKDM4EALDH1A1PKMHPGD | |
| SCHEMBL532198 | 0.69 | PIK3CA (0.61) | PIK3CAFYNKDM4EALDH1A1PKM | |
| SCHEMBL532016 | 0.68 | PIK3CA (1.00) | PIK3CAFYNKDM4EALDH1A1PKM | |
| SCHEMBL533182 | 0.68 | PIK3CA (0.71) | PIK3CAFYNMKNK1MKNK2KDM4E | |
| SCHEMBL15975809 | 0.68 | PIK3CA (0.77) | PIK3CAFYNMKNK1MKNK2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2414369-A1 | IMIDAZO [2, 1-B][ 1, 3, 4]THIADIAZOLE DERIVATIVES | Centro Nacional de Investigaciones Oncológicas (CNIO) (ES) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010112874-A1 | IMIDAZO [2, 1-B] [ 1, 3, 4 ] THIADIAZOLE DERIVATIVES | CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) (ES) | 2010-10-07 | — | — | WO | disclosed |