Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 18/20 | 0.62 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.54 |
| ▸ | BRD2 | P25440 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31490089 | 0.88 | BRD4 (0.54) | BRD4CREBBP | |
| SCHEMBL7413152 | 0.84 | BRD4 (0.54) | BRD4CREBBPBRD2 | |
| SCHEMBL9768375 | 0.84 | BRD4 (0.56) | BRD4CREBBPBRD2MAPTHPGD | |
| SCHEMBL7423824 | 0.84 | BRD4 (0.60) | BRD4CREBBPBRD2HPGDGFER | |
| SCHEMBL7409687 | 0.81 | BRD4 (0.57) | BRD4CREBBPBRD2HPGDGFER | |
| SCHEMBL4024924 | 0.81 | KDM4E (0.49) | BRD4KDM4EMAPT | |
| SCHEMBL4024521 | 0.79 | ITGB3 (0.47) | BRD4 | |
| SCHEMBL10414690 | 0.78 | BRD4 (0.50) | BRD4CREBBP | |
| SCHEMBL7434007 | 0.78 | BRD4 (0.50) | BRD4CREBBPBRD2 | |
| SCHEMBL7442306 | 0.78 | BRD4 (0.50) | BRD4CREBBPBRD2HPGDGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007144379-A1 | BICYCLIC COMPOUNDS USEFUL AS CATHEPSIN S INBHIBITORS | MEDIVIR AB (SE) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007144379-A1 | BICYCLIC COMPOUNDS USEFUL AS CATHEPSIN S INBHIBITORS | MEDIVIR AB (SE) | 2007-12-21 | — | — | WO | disclosed |
| WO-2006064286-A1 | CATHEPSIN S INHIBITORS | MEDIVIR UK LTD (GB) | 2006-06-22 | — | — | WO | disclosed |
| WO-2006064286-A1 | CATHEPSIN S INHIBITORS | MEDIVIR UK LTD (GB) | 2006-06-22 | — | — | WO | disclosed |