Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | S100A4 | P26447 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | NSD2 | O96028 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5328866 | 0.80 | TDP1 (0.42) | TDP1S100A4HPGDKDM4EHSD17B10 | |
| SCHEMBL5328420 | 0.79 | TDP1 (0.41) | TDP1S100A4ALDH1A1KMT2AMEN1 | |
| SCHEMBL5326748 | 0.79 | TDP1 (0.41) | TDP1S100A4ALDH1A1KDM4EMAPT | |
| SCHEMBL14233618 | 0.77 | ALDH1A1 (0.41) | ALDH1A1HPGDHTTKDM4EMAPT | |
| SCHEMBL14386783 | 0.69 | TDP1 (0.49) | TDP1S100A4ALDH1A1HPGDKMT2A | |
| SCHEMBL5330070 | 0.68 | TDP1 (0.47) | TDP1S100A4ALDH1A1HPGDKDM4E | |
| SCHEMBL28113788 | 0.68 | TDP1 (0.36) | TDP1S100A4ALDH1A1SMN1; SMN2 | |
| SCHEMBL7898077 | 0.65 | NSD2 (0.40) | TDP1S100A4ALDH1A1HPGDKDM4E | |
| SCHEMBL10883313 | 0.65 | KMT2A (0.49) | TDP1ALDH1A1HPGDHTTKDM4E | |
| SCHEMBL11241564 | 0.64 | TDP1 (0.42) | TDP1S100A4ALDH1A1HPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007134328-A2 | GELDANAMYCINS AND THEIR QUINONE MOIETIES INHIBIT CANCER BY ACTING ON MITOCHONDRIAL VOLTAGE-DEPENDENT ANION CHANNEL (VDAC) PROTEIN | VAN ANDEL RESEARCH INSTITUTE (US) | 2007-11-22 | — | — | WO | claimed |
| WO-2007134328-A2 | GELDANAMYCINS AND THEIR QUINONE MOIETIES INHIBIT CANCER BY ACTING ON MITOCHONDRIAL VOLTAGE-DEPENDENT ANION CHANNEL (VDAC) PROTEIN | VAN ANDEL RESEARCH INSTITUTE (US) | 2007-11-22 | — | — | WO | disclosed |
| WO-2007134328-A2 | GELDANAMYCINS AND THEIR QUINONE MOIETIES INHIBIT CANCER BY ACTING ON MITOCHONDRIAL VOLTAGE-DEPENDENT ANION CHANNEL (VDAC) PROTEIN | VAN ANDEL RESEARCH INSTITUTE (US) | 2007-11-22 | — | — | WO | disclosed |