Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1340890 | 0.93 | KMT2A (0.44) | KMT2AMEN1CYP2D6ALDH1A1ALOX15 | |
| SCHEMBL3909614 | 0.92 | KMT2A (0.47) | KMT2AMEN1CYP2D6ALDH1A1ALOX15 | |
| SCHEMBL5278967 | 0.89 | HDAC1 (0.41) | KMT2AMEN1CYP2D6ALDH1A1ALOX15 | |
| SCHEMBL1341532 | 0.86 | MAPT (0.49) | KMT2AMEN1CYP2D6ALDH1A1ALOX15 | |
| SCHEMBL12442147 | 0.81 | KMT2A (0.50) | KMT2AMEN1CYP2D6ALDH1A1TDP1 | |
| SCHEMBL1339192 | 0.79 | MAPT (0.46) | KMT2AMEN1CYP2D6ALOX15TDP1 | |
| SCHEMBL1342269 | 0.79 | MAPT (0.46) | KMT2AMEN1CYP2D6ALOX15TDP1 | |
| SCHEMBL9267287 | 0.79 | ABL1 (0.53) | KMT2AMEN1CYP2D6ALDH1A1ALOX15 | |
| SCHEMBL1347939 | 0.79 | RAB9A (0.55) | KMT2AMEN1CYP2D6ALDH1A1ALOX15 | |
| SCHEMBL1342546 | 0.78 | KMT2A (0.47) | KMT2AMEN1CYP2D6TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007135417-A1 | BENZOTRIAZEPINONE DERIVATIVES | JAMES BLACK FOUNDATION (GB) | 2007-11-29 | — | — | WO | disclosed |