SCHEMBL5330199

SCHEMBL5330199

Cc1cc(O)c2c(Cc3ccccc3)c(C)c(=O)oc2c1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 8/20 0.65
ALDH1A1 P00352 6/20 0.65
MAPT P10636 3/20 0.65
PTGDR2 Q9Y5Y4 1/20 0.60
GAA P10253 4/20 0.53
NPSR1 Q6W5P4 2/20 0.53
GLA P06280 1/20 0.53
HSD17B3 P37058 1/20 0.53
ERAP1 Q9NZ08 1/20 0.53
SAE1 Q9UBE0 1/20 0.53
UBA2 Q9UBT2 1/20 0.53
DRD4 P21917 1/20 0.52
NQO1 P15559 2/20 0.51
MAPK1 P28482 3/20 0.50
ALOX15 P16050 1/20 0.50
TSHR P16473 1/20 0.50
HPGD P15428 4/20 0.49
LMNA P02545 1/20 0.49
RXFP1 Q9HBX9 3/20 0.49
HSD17B10 Q99714 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5328894 0.90 KDM4E (0.81) KDM4EALDH1A1MAPTPTGDR2GAA
SCHEMBL5325401 0.81 KDM4E (0.64) KDM4EALDH1A1MAPTPTGDR2GAA
SCHEMBL5329160 0.80 PTGDR2 (0.58) KDM4EALDH1A1MAPTPTGDR2SAE1
SCHEMBL3786044 0.79 KDM4E (1.00) KDM4EALDH1A1MAPTPTGDR2GAA
SCHEMBL5331673 0.77 KDM4E (0.62) KDM4EALDH1A1MAPTPTGDR2GAA
SCHEMBL14315163 0.77 KDM4E (0.77) KDM4EALDH1A1MAPTPTGDR2GAA
SCHEMBL5330181 0.77 KDM4E (0.62) KDM4EALDH1A1MAPTPTGDR2GAA
SCHEMBL5330767 0.77 KDM4E (0.62) KDM4EALDH1A1MAPTPTGDR2GAA
SCHEMBL5328637 0.77 KDM4E (0.62) KDM4EALDH1A1MAPTPTGDR2GAA
SCHEMBL14346980 0.75 PTGDR2 (1.00) KDM4EALDH1A1MAPTPTGDR2GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007144625-A1 2-OXO-2H-CHROMENE COMPOUNDS ARGENTA DISCOVERY LIMITED (GB) 2007-12-21 WO disclosed