Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 5/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 5/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 5/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 5/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 5/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | WDR5 | P61964 | 2/20 | 0.37 |
| ▸ | BRS3 | P32247 | 2/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | ATP1A1 | P05023 | 1/20 | 0.37 |
| ▸ | ATP1B1 | P05026 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Agn-201904 SCHEMBL29596867 | 1.00 | CYP2C9 (0.41) | CYP2C9KMT2AMEN1PSEN1PSEN2 | |
| Agn-201904 SCHEMBL5764653 | 1.00 | CYP2C9 (0.41) | CYP2C9KMT2AMEN1PSEN1PSEN2 | |
| Agn-201904 SCHEMBL2245875 | 1.00 | CYP2C9 (0.41) | CYP2C9KMT2AMEN1PSEN1PSEN2 | |
| Agn-201904 SCHEMBL5764638 | 0.99 | CYP2C9 (0.40) | CYP2C9KMT2AMEN1PSEN1PSEN2 | |
| SCHEMBL19795374 | 0.94 | PSEN1 (0.42) | CYP2C9KMT2AMEN1PSEN1PSEN2 | |
| SCHEMBL5762457 | 0.94 | CYP2C9 (0.40) | CYP2C9KMT2AMEN1PSEN1PSEN2 | |
| SCHEMBL12353538 | 0.94 | CYP2C9 (0.41) | CYP2C9KMT2AMEN1PSEN1PSEN2 | |
| SCHEMBL5332714 | 0.94 | CYP2C9 (0.42) | CYP2C9KMT2AMEN1PSEN1PSEN2 | |
| SCHEMBL5763595 | 0.94 | CYP2C9 (0.42) | CYP2C9KMT2AMEN1PSEN1PSEN2 | |
| Agn-201904 SCHEMBL2510925 | 0.94 | CYP2C9 (0.41) | CYP2C9KMT2AMEN1PSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007073301-A1 | BENZOIMIDAZOLE DERIVATIVES AS PRODRUGS OF PROTON PUMP INHIBITORS | ASTRAZENECA AB (SE) | 2007-06-28 | — | — | WO | disclosed |
| WO-2007073301-A1 | BENZOIMIDAZOLE DERIVATIVES AS PRODRUGS OF PROTON PUMP INHIBITORS | ASTRAZENECA AB (SE) | 2007-06-28 | — | — | WO | disclosed |