Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.33 |
| ▸ | PNMT | P11086 | 1/20 | 0.32 |
| ▸ | CTSB | P07858 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5412466 | 0.85 | ALDH1A1 (0.47) | ALDH1A1KDM4EMEN1KMT2ALMNA | |
| SCHEMBL27921135 | 0.84 | ALDH1A1 (0.46) | ALDH1A1KDM4EMEN1KMT2ALMNA | |
| SCHEMBL28057995 | 0.81 | ALDH1A1 (0.44) | ALDH1A1KDM4EMEN1KMT2ALMNA | |
| SCHEMBL10180094 | 0.81 | ALDH1A1 (0.44) | ALDH1A1KDM4EMEN1KMT2ALMNA | |
| SCHEMBL10180394 | 0.80 | ALDH1A1 (0.43) | ALDH1A1KDM4EMEN1KMT2ALMNA | |
| SCHEMBL10179424 | 0.78 | ALDH1A1 (0.42) | ALDH1A1KDM4EMEN1KMT2ALMNA | |
| SCHEMBL1204858 | 0.77 | ALDH1A1 (0.54) | ALDH1A1KDM4EMEN1KMT2ALMNA | |
| SCHEMBL707747 | 0.76 | ALDH1A1 (0.49) | ALDH1A1KDM4EMEN1KMT2ALMNA | |
| SCHEMBL4277651 | 0.76 | ALDH1A1 (0.49) | ALDH1A1KDM4EMEN1KMT2ALMNA | |
| SCHEMBL11079398 | 0.76 | ALDH1A1 (0.49) | ALDH1A1KDM4EMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863771-A2 | BENZAZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE AS B-SECRETASE INHIBITORS | Transtech Pharma, Inc. (US) | 2007-12-12 | — | — | EP | claimed |
| WO-2006099379-A2 | BENZAZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE AS B-SECRETASE INHIBITORS | TRANSTECH PHARMA, INC. (US) | 2006-09-21 | — | — | WO | claimed |
| EP-1863771-A2 | BENZAZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE AS B-SECRETASE INHIBITORS | Transtech Pharma, Inc. (US) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006099379-A2 | BENZAZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE AS B-SECRETASE INHIBITORS | TRANSTECH PHARMA, INC. (US) | 2006-09-21 | — | — | WO | disclosed |