Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | AGXT | P21549 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15012421 | 0.79 | KDM4E (0.46) | KDM4EPOLBTSHRIDO1AGXT | |
| SCHEMBL11249114 | 0.79 | KDM4E (0.46) | KDM4EPOLBTSHRIDO1AGXT | |
| SCHEMBL11633545 | 0.77 | KDM4E (0.47) | KDM4EPOLBTSHRIDO1AGXT | |
| SCHEMBL283052 | 0.77 | KDM4E (0.47) | KDM4EPOLBTSHRIDO1AGXT | |
| SCHEMBL1356758 | 0.76 | TSHR (0.48) | KDM4EPOLBTSHRIDO1AGXT | |
| SCHEMBL7943850 | 0.75 | KDM4E (0.46) | KDM4EPOLBTSHRIDO1AGXT | |
| SCHEMBL18560211 | 0.75 | KDM4E (0.42) | KDM4EPOLBTSHRIDO1AGXT | |
| SCHEMBL8096968 | 0.75 | KDM4E (0.42) | KDM4EPOLBTSHRIDO1ALDH1A1 | |
| SCHEMBL29197946 | 0.75 | TSHR (0.43) | KDM4EPOLBTSHRIDO1AGXT | |
| SCHEMBL584498 | 0.74 | CYP2C19 (0.48) | KDM4EPOLBTSHRIDO1AGXT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8865149-B2 | Polymeric reagents comprising a ketone or a related functional group | NEKTAR THERAPEUTICS (US) | 2014-10-21 | — | — | US | disclosed |
| US-20070166277-A1 | Polymeric reagents comprising a ketone or a related functional group | NEKTAR THERAPEUTICS | 2007-07-19 | — | — | US | disclosed |
| US-7208145-B2 | Useful for providing conjugates with other substances | NEKTAR THERAPEUTICS AL, CORPORATION (US) | 2007-04-24 | — | — | US | disclosed |
| CN-1744918-A | Polymeric reagents comprising a ketone or a related functional group | NEKTAR THERAPEUTICS AL CORP (US) | 2006-03-08 | — | — | CN | disclosed |
| EP-1581260-A2 | POLYMERIC REAGENTS COMPRISING A KETONE OR A RELATED FUNCTIONAL GROUP | Nektar Therapeutics Al, Corporation (US) | 2005-10-05 | — | — | EP | disclosed |
| US-20050031576-A1 | Water-soluble polymer segment and a functional group such as a ketone, a ketone hydrate, a thione, wherein the functional group is part of a cyclic structure attached to polymer segment through either a direct covalent bond or through one or more atoms; useful for forming polymer-active agent conjugates | NEKTAR THERAPEUTICS | 2005-02-10 | — | — | US | disclosed |
| WO-2004060406-A2 | POLYMERIC REAGENTS COMPRISING A KETONE OR A RELATED FUNCTIONAL GROUP | NEKTAR THERAPEUTICS AL, CORPORATION (US) | 2004-07-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070166277-A1 | Polymeric reagents comprising a ketone or a related functional group | TKT, KHK, KLK5 | KDM4E 365/4885POLB 3816/4885TSHR 3097/4885 |
| US-20050031576-A1 | Water-soluble polymer segment and a functional group such as a ketone, a ketone hydrate, a thione, wherein the functional group is part of a cyclic structure attached to polymer segment through either a direct covalent bond or through one or more atoms; useful for forming polymer-active agent conjugates | TKT, KHK, TK1 | KDM4E 595/4885POLB 3753/4885TSHR 2446/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.