Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.70 |
| ▸ | MAPT | P10636 | 4/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.70 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 5/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | RECQL | P46063 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5330937 | 1.00 | TP53 (0.76) | TP53ALDH1A1MAPTLMNAPTK2 | |
| SCHEMBL14542267 | 0.87 | TP53 (0.79) | TP53ALDH1A1MAPTLMNAPTK2 | |
| SCHEMBL14542024 | 0.86 | TP53 (0.78) | TP53ALDH1A1MAPTLMNAPTK2 | |
| SCHEMBL5328282 | 0.84 | TP53 (0.75) | TP53ALDH1A1MAPTLMNAKMT2A | |
| SCHEMBL5328274 | 0.84 | TP53 (0.75) | TP53ALDH1A1MAPTLMNAKMT2A | |
| SCHEMBL13856360 | 0.81 | PTK2 (0.77) | ALDH1A1MAPTLMNAPTK2KMT2A | |
| SCHEMBL5334648 | 0.81 | MEN1 (0.81) | TP53ALDH1A1MAPTPTK2KMT2A | |
| SCHEMBL14542106 | 0.80 | TP53 (0.69) | TP53ALDH1A1MAPTLMNAPTK2 | |
| SCHEMBL14542264 | 0.80 | HPGD (0.65) | TP53ALDH1A1MAPTLMNAKMT2A | |
| SCHEMBL14542416 | 0.80 | TP53 (0.69) | TP53ALDH1A1MAPTLMNAPTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007047394-A2 | THIOTRIAZOLYL DERIVATIVES | EPIX DELAWARE, INC. (US) | 2007-04-26 | — | — | WO | claimed |
| WO-2007047394-A2 | THIOTRIAZOLYL DERIVATIVES | EPIX DELAWARE, INC. (US) | 2007-04-26 | — | — | WO | disclosed |
| WO-2007047394-A2 | THIOTRIAZOLYL DERIVATIVES | EPIX DELAWARE, INC. (US) | 2007-04-26 | — | — | WO | disclosed |