Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 8/20 | 0.71 |
| ▸ | CA12 | O43570 | 9/20 | 0.46 |
| ▸ | CA1 | P00915 | 9/20 | 0.46 |
| ▸ | CA2 | P00918 | 9/20 | 0.46 |
| ▸ | CA9 | Q16790 | 9/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TNF | P01375 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2121280 | 0.88 | PIK3CA (0.57) | PIK3CACA12CA1CA2CA9 | |
| SCHEMBL452469 | 0.87 | PIK3CA (0.73) | PIK3CACA12CA1CA2CA9 | |
| SCHEMBL532184 | 0.85 | PIK3CA (0.75) | PIK3CACA12CA1CA2CA9 | |
| SCHEMBL532669 | 0.85 | PIK3CA (0.54) | PIK3CACA12CA1CA2CA9 | |
| SCHEMBL533328 | 0.83 | PIK3CA (0.49) | PIK3CACA12CA1CA2CA9 | |
| SCHEMBL2121698 | 0.83 | PIK3CA (0.49) | PIK3CACA12CA1CA2CA9 | |
| SCHEMBL2120594 | 0.83 | PIK3CA (0.56) | PIK3CACA12CA1CA2CA9 | |
| SCHEMBL533128 | 0.83 | PIK3CA (1.00) | PIK3CATNF | |
| SCHEMBL532104 | 0.82 | PIK3CA (0.55) | PIK3CA | |
| SCHEMBL532239 | 0.81 | ALPL (0.48) | PIK3CACA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2414369-B1 | IMIDAZO[2,1-B][1,3,4]THIADIAZOLE DERIVATIVES | FUNDACIÓN CT NAC DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (ES) | 2015-08-12 | — | — | EP | disclosed |
| US-8815918-B2 | Imidazo [2, 1-B] [1, 3, 4] thiadiazole derivatives | CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) (ES) | 2014-08-26 | — | — | US | disclosed |
| EP-2414369-A1 | IMIDAZO [2, 1-B][ 1, 3, 4]THIADIAZOLE DERIVATIVES | Centro Nacional de Investigaciones Oncológicas (CNIO) (ES) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010112874-A1 | IMIDAZO [2, 1-B] [ 1, 3, 4 ] THIADIAZOLE DERIVATIVES | CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) (ES) | 2010-10-07 | — | — | WO | disclosed |