SCHEMBL5331329

SCHEMBL5331329

ClC1=C(Cl)Oc2c(ccc(Cl)c2Cl)O1

nearest known ligand 0.63

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
AHR P35869 12/20 0.63
CYP3A4 P08684 1/20 0.32
MAPK1 P28482 1/20 0.32
FLT1 P17948 1/20 0.31
NOTUM Q6P988 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29449476 1.00 AHR (0.63) AHRCYP3A4MAPK1FLT1NOTUM
SCHEMBL9579677 0.87
SCHEMBL8712405 0.83 AHR (0.72) AHRCYP3A4MAPK1FLT1NOTUM
SCHEMBL8718012 0.83 AHR (0.72) AHRCYP3A4MAPK1FLT1NOTUM
SCHEMBL8712941 0.83 AHR (0.72) AHRCYP3A4MAPK1FLT1NOTUM
SCHEMBL1806662 0.79 AHR (0.67) AHRCYP3A4MAPK1
SCHEMBL5960341 0.77 AHR (0.70) AHRFLT1
SCHEMBL10350071 0.77 AHR (1.00) AHRFLT1
SCHEMBL5693594 0.74 AHR (0.60) AHRCYP3A4MAPK1
SCHEMBL2465673 0.70 AHR (0.55) AHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0888153-A1 METHOD FOR HOT AND SUPERCRITICAL WATER OXIDATION OF MATERIAL USING SPECIFIC REACTANTS SRI INTERNATIONAL (US) 1999-01-07 EP claimed
US-5837149-A Method for hot and supercritical water oxidation of material with addition of specific reactants SRI INTERNATIONAL (US) 1998-11-17 US claimed
US-5746926-A Method for hydrothermal oxidation of halogenated organic compounds with addition of specific reactants SRI INTERNATIONAL (US) 1998-05-05 US claimed
WO-1997034660-A1 METHOD FOR HOT AND SUPERCRITICAL WATER OXIDATION OF MATERIAL USING SPECIFIC REACTANTS SRI INTERNATIONAL (US) 1997-09-25 WO claimed
US-4794871-A Method and installation for the treatment of material contaminated with toxic organic compounds ENVIRONMENT PROTECTION ENGINEERS, INC. (US) 1989-01-03 US claimed
CN-114644627-B AhR inhibitors and uses thereof 山东轩竹医药科技有限公司 2024-06-11 CN disclosed
CN-115698005-B Fused ring AhR inhibitors 山东轩竹医药科技有限公司 2024-02-06 CN disclosed
CN-114369097-B Heteroaromatic AhR inhibitors 山东轩竹医药科技有限公司 2023-07-14 CN disclosed
CN-114181212-B Pyridazinone AhR inhibitors 山东轩竹医药科技有限公司 2023-06-06 CN disclosed
CN-114181208-B Tri-fused ring AhR inhibitor and application thereof 山东轩竹医药科技有限公司 2023-05-02 CN disclosed
CN-115698005-A Fused ring AhR inhibitors 山东轩竹医药科技有限公司 2023-02-03 CN disclosed
CN-115636828-A Tricyclic AhR inhibitors 山东轩竹医药科技有限公司 2023-01-24 CN disclosed
WO-1997034660-A1 METHOD FOR HOT AND SUPERCRITICAL WATER OXIDATION OF MATERIAL USING SPECIFIC REACTANTS SRI INTERNATIONAL (US) 1997-09-25 WO disclosed
WO-1997032972-A1 IMMORTALIZED HEPATOCYTES RHODE ISLAND HOSPITAL (US) 1997-09-12 WO disclosed
EP-0478445-A1 Composition for cleaning and decontaminating, in particular surgical instruments PETERS (FR) 1992-04-01 EP disclosed
EP-0157270-B1 PROCESS FOR THE PREPARATION OF TETRACHLORO-BENZO-1,4-DIOXENES BAYER AG (DE) 1988-06-15 EP disclosed
EP-0156195-B1 METHOD FOR THE PREPARATION OF 2,2,3,3-TETRACHLORO-2,3-DIHYDRO-1,4-BENZODIOXINES, AND THE COMPOUND 6-ISOCYANATO-2,2,3,3-TETRACHLORO-2,3-DIHYDRO-1,4-BENZODIOXINE BAYER AG (DE) 1988-05-11 EP disclosed
US-4581466-A REACTING A PYROCATECHOL COMPOUND WITH TETRACHLOROETHYLENE CARONATE BAYER AKTIENGESELLSCHAFT (DE) 1986-04-08 US disclosed
US-4564714-A CHLORINATION OF 2,5-DICHLOROPHENOL, ACID CATALYSTS GIVAUDAN CORPORATION (US) 1986-01-14 US disclosed
EP-0157270-A2 Process for the preparation of tetrachloro-benzo-1,4-dioxenes BAYER AG (DE) 1985-10-09 EP disclosed