Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | TYK2 | P29597 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
| ▸ | DPP4 | P27487 | 2/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4377598 | 0.78 | TDP1 (0.40) | TDP1 | |
| SCHEMBL1679032 | 0.78 | PSEN1 (0.46) | HTR1ADRD2HTR2ADRD3PSEN1 | |
| SCHEMBL4064938 | 0.77 | PSEN1 (0.39) | HTR1ADRD2HTR2ADRD3PSEN1 | |
| SCHEMBL5530336 | 0.74 | ALDH1A1 (0.48) | — | |
| SCHEMBL1960773 | 0.74 | — | — | |
| SCHEMBL29652939 | 0.73 | SMYD3 (0.46) | HTR1ADRD2HTR2ADRD3PSEN1 | |
| SCHEMBL24286326 | 0.71 | ALDH1A1 (0.44) | HTR1ADRD2HTR2ADRD3PSEN1 | |
| SCHEMBL23573233 | 0.71 | PSEN1 (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5130918 | 0.71 | TDP1 (0.44) | TDP1DRD2HTR2ADRD3 | |
| SCHEMBL8391325 | 0.70 | CA1 (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007103295-A2 | HALOGENATED SULFONAMIDE DERIVATIVES | H. LUNDBECK A/S (DK) | 2007-09-13 | — | — | WO | disclosed |
| US-20070213376-A1 | Halogenated sulfonamide derivatives | H. LUNDBECK A/S (DK) | 2007-09-13 | — | — | US | disclosed |
| WO-2007002126-A1 | ALKYL SULFONAMIDE DERIVATIVES | H. LUNDBECK A/S (DK) | 2007-01-04 | — | — | WO | disclosed |
| US-20060293341-A1 | Alkyl sulfonamide derivatives | H. LUNDBECK A/S (DK) | 2006-12-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070213376-A1 | Halogenated sulfonamide derivatives | NPY5R, NPY2R, SSTR5 | TDP1 3232/4885HTR1A 102/4885DRD2 534/4885 |
| US-20060293341-A1 | Alkyl sulfonamide derivatives | NPY5R, NPY1R, NPY4R | TDP1 2989/4885HTR1A 63/4885DRD2 849/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.