Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA3 | P07451 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA6 | P23280 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | DDO | Q99489 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 3/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27889736 | 0.84 | AOC3 (0.46) | HRH4HRH3AOC3CA12CA1 | |
| SCHEMBL28670716 | 0.77 | AOC3 (0.39) | HRH4HRH3AOC3CA12CA1 | |
| SCHEMBL9462932 | 0.73 | AOC3 (0.41) | HRH4HRH3AOC3CA12CA1 | |
| SCHEMBL20547348 | 0.72 | BRD4 (0.46) | HRH4HRH3AOC3CA12CA1 | |
| SCHEMBL6597824 | 0.72 | AOC3 (0.40) | HRH4HRH3AOC3CA12CA1 | |
| SCHEMBL11667140 | 0.71 | AOC3 (0.42) | HRH4HRH3AOC3CA12CA1 | |
| SCHEMBL29866067 | 0.71 | AOC3 (0.42) | HRH4HRH3AOC3CA12CA1 | |
| SCHEMBL6224361 | 0.71 | NPC1 (0.50) | PARP1POLBSMN1; SMN2 | |
| SCHEMBL30418698 | 0.71 | NPC1 (0.51) | AOC3CA12CA1CA3CA4 | |
| SCHEMBL21047717 | 0.69 | APAF1 (0.47) | HRH4HRH3AOC3CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117447471-A | Indole diketopiperazine compound, preparation method thereof and application thereof in preparation of osteoclast differentiation inhibitor | 广西中医药大学 | 2024-01-26 | — | — | CN | claimed |
| CN-110066283-A | A kind of Indolyl diketopiperazine compounds Alkaloid and its preparation method and application | 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) | 2019-07-30 | — | — | CN | claimed |
| CN-102911188-B | Sulfur-containing diindolyl diketopiperazine compounds and application thereof in preparing antineoplastic drugs | SOUTH CHINA SEA INST OCEANOLOG | 2015-01-07 | — | — | CN | claimed |
| CN-103435622-A | Spiro indole diketopiperazine alkaloid, and synthesis method and application of spiro indole diketopiperazine alkaloid | UNIV SHAANXI SCIENCE & TECH | 2013-12-11 | — | — | CN | claimed |
| CN-102669110-B | Application of indole diketopiperazine derivatives | INST OCEANOLOGY CHINESE ACAD | 2013-06-19 | — | — | CN | claimed |
| CN-102911188-A | Sulfur-containing diindolyl diketopiperazine compounds and application thereof in preparing antineoplastic drugs | SOUTH CHINA SEA INST OCEANOLOG | 2013-02-06 | — | — | CN | claimed |
| WO-2007037782-A2 | METHOD FOR TREATING PROSTATE CONDITIONS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2007-04-05 | — | — | WO | claimed |
| US-20060233809-A1 | Method for treating prostate conditions | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2006-10-19 | — | — | US | claimed |
| CN-116354946-B | Indolyl diketopiperazine derivative and strain derived from marine aspergillus as well as preparation methods and application of indolyl diketopiperazine derivative and strain | 浙江工业大学 | 2025-05-30 | — | — | CN | disclosed |
| CN-116354946-B | Indolyl diketopiperazine derivative and strain derived from marine aspergillus as well as preparation methods and application of indolyl diketopiperazine derivative and strain | 浙江工业大学 | 2025-05-30 | — | — | CN | disclosed |
| CN-117964631-A | Indole diketopiperazine compound and preparation method and application thereof | 中国农业科学院烟草研究所(中国烟草总公司青州烟草研究所) | 2024-05-03 | — | — | CN | disclosed |
| CN-117447471-A | Indole diketopiperazine compound, preparation method thereof and application thereof in preparation of osteoclast differentiation inhibitor | 广西中医药大学 | 2024-01-26 | — | — | CN | disclosed |
| CN-116354946-A | Indolyl diketopiperazine derivative and strain derived from marine aspergillus as well as preparation methods and application of indolyl diketopiperazine derivative and strain | 浙江工业大学 | 2023-06-30 | — | — | CN | disclosed |
| CN-116354946-A | Indolyl diketopiperazine derivative and strain derived from marine aspergillus as well as preparation methods and application of indolyl diketopiperazine derivative and strain | 浙江工业大学 | 2023-06-30 | — | — | CN | disclosed |
| US-20060233809-A1 | Method for treating prostate conditions | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2006-10-19 | — | — | US | disclosed |
| US-20050255084-A1 | Use of a half-transporter protein of the abcg-family for selecting cells and in gene therapy | SOLVO BIOTECHNOLOGY (HU) | 2005-11-17 | — | — | US | disclosed |
| EP-1442057-A1 | USE OF A HALF-TRANSPORTER PROTEIN OF THE ABCG-FAMILY FOR SELECTING CELLS AND IN GENE THERAPY | Solvo Biotechnology Inc. (HU) | 2004-08-04 | — | — | EP | disclosed |
| US-6608193-B2 | Forming an intermediate by reacting the support-bound amino-substituted-tetrahydroisoquinoline compound with a reagent; and cyclizatively cleaving support-bound amino-substituted-tetrahydroisoquinoline compound | THE PROCTER & GAMBLE COMPANY | 2003-08-19 | — | — | US | disclosed |
| WO-2003035685-A1 | USE OF A HALF-TRANSPORTER PROTEIN OF THE ABCG-FAMILY FOR SELECTING CELLS AND IN GENE THERAPY | SOLVO BIOTECHNOLOGY INC. (HU) | 2003-05-01 | — | — | WO | disclosed |
| US-20020077480-A1 | Methods for synthesis of amino-tetrahydroisoquinoline ring compounds | PROCTER & GAMBLE COMPANY, THE | 2002-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020077480-A1 | Methods for synthesis of amino-tetrahydroisoquinoline ring compounds | ASNS, QPCT, DAO | HRH4 648/4885HRH3 606/4885AOC3 756/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.