Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.32 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | OXTR | P30559 | 1/20 | 0.31 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5200823 | 0.90 | ALDH1A1 (0.32) | SMN1; SMN2MAPK1GAAL3MBTL1ALDH1A1 | |
| SCHEMBL2003485 | 0.77 | SMN1; SMN2 (0.54) | SMN1; SMN2MAPK1GAAL3MBTL1ALDH1A1 | |
| SCHEMBL1999789 | 0.72 | NR1H2 (0.49) | SMN1; SMN2ADRB2ADRB1 | |
| SCHEMBL2002996 | 0.72 | NR1H2 (0.50) | MAPK1GAAALDH1A1MAPTHTT | |
| SCHEMBL1997180 | 0.70 | SMN1; SMN2 (0.49) | SMN1; SMN2MAPK1GAAL3MBTL1ALDH1A1 | |
| SCHEMBL1997881 | 0.70 | TOP2A (0.42) | SMN1; SMN2MAPK1GAAL3MBTL1ALDH1A1 | |
| SCHEMBL1999999 | 0.66 | NR1H2 (0.52) | SMN1; SMN2MAPK1L3MBTL1ALDH1A1MAPT | |
| SCHEMBL2000989 | 0.66 | CNR1 (0.38) | SMN1; SMN2MAPK1ALDH1A1MAPTLMNA | |
| SCHEMBL2000527 | 0.66 | NR1H2 (0.44) | L3MBTL1ALDH1A1MAPTNPSR1TP53 | |
| SCHEMBL2003178 | 0.64 | NR1H2 (0.53) | MAPK1GAAL3MBTL1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838687-A1 | NON-ANILINIC DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2007-10-03 | — | — | EP | disclosed |
| WO-2006073366-A1 | NON-ANILINIC DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2006-07-13 | — | — | WO | disclosed |