Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 11/20 | 0.57 |
| ▸ | NPC1 | O15118 | 10/20 | 0.57 |
| ▸ | RAB9A | P51151 | 10/20 | 0.57 |
| ▸ | MAPT | P10636 | 10/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.57 |
| ▸ | LMNA | P02545 | 5/20 | 0.57 |
| ▸ | HTT | P42858 | 3/20 | 0.57 |
| ▸ | RECQL | P46063 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.53 |
| ▸ | TP53 | P04637 | 5/20 | 0.53 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5340173 | 0.81 | RAB9A (0.69) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL31649865 | 0.80 | SMN1; SMN2 (0.58) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL31650451 | 0.78 | SMN1; SMN2 (0.58) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL11903011 | 0.72 | SMN1; SMN2 (0.72) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL31649581 | 0.71 | CYP1A2 (0.60) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL11791035 | 0.68 | NPC1 (0.46) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL31650221 | 0.67 | RAB9A (0.46) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL31650070 | 0.66 | TP53 (0.43) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL17264300 | 0.66 | SMN1; SMN2 (0.60) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL17261641 | 0.66 | SMN1; SMN2 (0.66) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007067710-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS FOR MODULATING TRPV1 | AMPHORA DISCOVERY CORPORATION (US) | 2007-06-14 | — | — | WO | claimed |
| WO-2007067710-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS FOR MODULATING TRPV1 | AMPHORA DISCOVERY CORPORATION (US) | 2007-06-14 | — | — | WO | disclosed |