Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 8/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 7/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CIT | O14578 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | HLA-A | P04439 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7914610 | 0.96 | FLT1 (0.55) | FLT1GAAMAPK1KMT2AMEN1 | |
| SCHEMBL5332250 | 0.85 | FLT1 (0.62) | FLT1GAAMAPK1KMT2AMEN1 | |
| SCHEMBL7918121 | 0.76 | LMNA (0.56) | FLT1KMT2AMEN1PKMOPRM1 | |
| SCHEMBL7914591 | 0.75 | LMNA (0.58) | KMT2AMEN1PKMOPRM1OPRD1 | |
| SCHEMBL8204447 | 0.73 | FLT1 (1.00) | FLT1KMT2AMEN1KDRCIT | |
| SCHEMBL9807640 | 0.73 | FLT1 (0.77) | FLT1KMT2AMEN1KDRCYP1A2 | |
| SCHEMBL27466742 | 0.73 | PDE5A (0.66) | FLT1 | |
| SCHEMBL4814640 | 0.72 | FLT1 (0.48) | FLT1GAAMAPK1CYP1A2 | |
| SCHEMBL27381270 | 0.72 | PDE5A (0.46) | FLT1GAAKMT2AMEN1 | |
| SCHEMBL4817310 | 0.71 | CYP2A6 (0.49) | FLT1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5849741-A | Fused pyridazine compounds | EISAI CO., LTD. (JP) | 1998-12-15 | — | — | US | disclosed |
| EP-0722936-A1 | FUSED PYRIDAZINE COMPOUND | Eisai Co., Ltd. (JP) | 1996-07-24 | — | — | EP | disclosed |