Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 8/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | ACKR3 | P25106 | 3/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1996473 | 0.93 | NAMPT (0.39) | NAMPTUSP30PRMT5WDR77TACR1 | |
| SCHEMBL5332275 | 0.92 | NR1H2 (0.39) | NAMPTUSP30PRMT5WDR77TACR1 | |
| SCHEMBL2007872 | 0.90 | NR1H2 (0.35) | NAMPT | |
| SCHEMBL1996471 | 0.85 | NR1H2 (0.43) | NAMPTUSP30PRMT5WDR77TACR1 | |
| SCHEMBL2006144 | 0.82 | NAMPT (0.44) | NAMPTUSP30TACR1KDM4EPKM | |
| SCHEMBL2007867 | 0.81 | NR1H2 (0.46) | NAMPT | |
| SCHEMBL2006147 | 0.74 | NAMPT (0.44) | NAMPTUSP30TACR1KDM4EPKM | |
| SCHEMBL2004758 | 0.73 | NR1H2 (0.35) | USP30KDM4EPKM | |
| SCHEMBL2001032 | 0.72 | ALDH1A1 (0.47) | USP30KDM4EPKM | |
| SCHEMBL24458928 | 0.70 | NR1H2 (0.49) | NAMPTPRMT5WDR77RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838687-A1 | NON-ANILINIC DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2007-10-03 | — | — | EP | disclosed |
| WO-2006073366-A1 | NON-ANILINIC DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2006-07-13 | — | — | WO | disclosed |