Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 6/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HTR1F | P30939 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 6/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 6/20 | 0.34 |
| ▸ | RELA | Q04206 | 6/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | WDR5 | P61964 | 1/20 | 0.33 |
| ▸ | RBBP5 | Q15291 | 1/20 | 0.33 |
| ▸ | ASH2L | Q9UBL3 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5328471 | 0.89 | HTR1B (0.72) | HTR1BKCNH2KDM4ENFKB1NFKB2 | |
| SCHEMBL5332698 | 0.88 | HTR1B (0.57) | HTR1BKCNH2KDM4ENFKB1NFKB2 | |
| SCHEMBL4250243 | 0.86 | HTR1B (0.71) | HTR1BKCNH2NFKB1NFKB2RELA | |
| SCHEMBL5308402 | 0.85 | HTR1B (0.57) | HTR1BKCNH2KDM4ENFKB1NFKB2 | |
| SCHEMBL5309051 | 0.85 | HTR1B (0.58) | HTR1BKCNH2KDM4EHTR1FNFKB1 | |
| SCHEMBL5308451 | 0.83 | HTR1B (0.78) | HTR1BKCNH2KDM4EHTR1AHTR1D | |
| SCHEMBL14529770 | 0.82 | HTR1B (0.66) | HTR1BKCNH2NFKB1NFKB2RELA | |
| SCHEMBL5308377 | 0.82 | HTR1B (0.57) | HTR1BKCNH2KDM4ENFKB1NFKB2 | |
| SCHEMBL5308374 | 0.82 | HTR1B (0.59) | HTR1BKCNH2KDM4EKMT2AMEN1 | |
| SCHEMBL4247598 | 0.82 | HTR1B (0.65) | HTR1BKCNH2KDM4EHTR1AHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070135442-A1 | Chroman compounds | ASTRAZENECA AB (SE) | 2007-06-14 | — | — | US | disclosed |
| WO-2007053094-A1 | CHROMAN COMPOUNDS AS 5 -HTlB ANTAGONISTS | ASTRAZENECA AB (SE) | 2007-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135442-A1 | Chroman compounds | CYP3A43, CYP2C9, CYP2C8 | HTR1B 592/4885KCNH2 1018/4885KDM4E 2353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.