Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 3/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.38 |
| ▸ | CDK9 | P50750 | 3/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 3/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 2/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.36 |
| ▸ | MYLK | Q15746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8236105 | 0.85 | MKNK1 (0.46) | MKNK1MKNK2MAPK8MAPK9MAPK10 | |
| SCHEMBL8236075 | 0.85 | MAPK8 (0.43) | MKNK1MKNK2MAPK8MAPK9MAPK10 | |
| SCHEMBL8233939 | 0.79 | MAPK8 (0.44) | MKNK1MKNK2MAPK8MAPK9MAPK10 | |
| SCHEMBL5314694 | 0.77 | MAPK8 (0.50) | MAPK8MAPK9MAPK10ALDH1A1TSHR | |
| SCHEMBL5314464 | 0.75 | MAPK8 (0.56) | MAPK8MAPK9MAPK10CDK2CCNA2 | |
| SCHEMBL5311813 | 0.75 | TSHR (0.47) | MAPK8MAPK9MAPK10ALDH1A1TSHR | |
| SCHEMBL8235073 | 0.73 | MAPK10 (0.61) | MKNK2MAPK8MAPK9MAPK10CDK2 | |
| SCHEMBL8232791 | 0.72 | MAPK8 (0.59) | MKNK1MAPK8MAPK9MAPK10CDK2 | |
| SCHEMBL8232786 | 0.71 | MAPK8 (0.58) | MAPK8MAPK9MAPK10CDK2CCNA2 | |
| SCHEMBL18365039 | 0.71 | TSHR (0.49) | MAPK8MAPK9MAPK10ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007129195-A2 | 4-PYRIMIDINE-5-AMINO-PYRAZOLE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-11-15 | — | — | WO | disclosed |