Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 3/20 | 0.56 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.56 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.56 |
| ▸ | IKBKB | O14920 | 5/20 | 0.55 |
| ▸ | CDK2 | P24941 | 9/20 | 0.50 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.50 |
| ▸ | CDK1 | P06493 | 5/20 | 0.44 |
| ▸ | CDK4 | P11802 | 4/20 | 0.44 |
| ▸ | CCND1 | P24385 | 3/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.43 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8232786 | 0.86 | MAPK8 (0.58) | MAPK8MAPK9MAPK10CDK2CDK1 | |
| SCHEMBL8235073 | 0.85 | MAPK10 (0.61) | MAPK8MAPK9MAPK10IKBKBCDK2 | |
| SCHEMBL8232791 | 0.83 | MAPK8 (0.59) | MAPK8MAPK9MAPK10IKBKBCDK2 | |
| SCHEMBL8227898 | 0.83 | IKBKB (0.60) | MAPK8MAPK9MAPK10IKBKBCDK2 | |
| SCHEMBL8233028 | 0.83 | MAPK8 (0.62) | MAPK8MAPK9MAPK10CDK2CCNE1 | |
| SCHEMBL5330022 | 0.82 | MAPK8 (0.54) | MAPK8MAPK9MAPK10CDK2CDK1 | |
| SCHEMBL8233252 | 0.78 | IKBKB (0.58) | MAPK8MAPK9MAPK10IKBKBCDK2 | |
| SCHEMBL8236075 | 0.77 | MAPK8 (0.43) | MAPK8MAPK9MAPK10CDK2CDK4 | |
| SCHEMBL5311813 | 0.76 | TSHR (0.47) | MAPK8MAPK9MAPK10 | |
| SCHEMBL5333417 | 0.75 | MKNK1 (0.41) | MAPK8MAPK9MAPK10CDK2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007129195-A2 | 4-PYRIMIDINE-5-AMINO-PYRAZOLE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-11-15 | — | — | WO | disclosed |
| WO-2007129195-A2 | 4-PYRIMIDINE-5-AMINO-PYRAZOLE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-11-15 | — | — | WO | disclosed |