Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 8/20 | 0.47 |
| ▸ | MAOA | P21397 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | CALML3 | P27482 | 1/20 | 0.45 |
| ▸ | SDHA | P31040 | 1/20 | 0.45 |
| ▸ | F10 | P00742 | 9/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5334630 | 0.91 | MAOB (0.48) | MAOBMAOALMNAPTGS1CALML3 | |
| Hydrochloric Acid SCHEMBL5334751 | 0.90 | MAOB (0.47) | MAOBMAOALMNAPTGS1CALML3 | |
| Citric Acid SCHEMBL5334822 | 0.89 | MAOB (0.49) | MAOBMAOALMNAPTGS1CALML3 | |
| SCHEMBL5333450 | 0.84 | MAOB (0.41) | MAOBMAOALMNAPTGS1CALML3 | |
| SCHEMBL7850811 | 0.81 | MAOA (0.68) | MAOBMAOALMNAPTGS1CALML3 | |
| SCHEMBL7850808 | 0.81 | MAOA (0.68) | MAOBMAOALMNAPTGS1CALML3 | |
| SCHEMBL8111378 | 0.79 | CALML3 (0.61) | MAOBMAOALMNAPTGS1CALML3 | |
| SCHEMBL8111373 | 0.79 | CALML3 (0.61) | MAOBMAOALMNAPTGS1CALML3 | |
| SCHEMBL14540833 | 0.79 | MAOB (0.55) | MAOBMAOALMNAPTGS1CALML3 | |
| SCHEMBL14541193 | 0.78 | MAOB (0.49) | MAOBMAOALMNAPTGS1CALML3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007040326-A1 | A NOVEL OXAZOLIDINONE FORMAMIDE DERIVATIVE AND PREPARATION METHOD THEROF | ILDONG PHARMACEUTICAL CO., LTD (KR) | 2007-04-12 | — | — | WO | disclosed |