Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K7 | O14733 | 10/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | TEK | Q02763 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 8/20 | 0.39 |
| ▸ | TNNI3K | Q59H18 | 5/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.38 |
| ▸ | BRAF | P15056 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5448231 | 0.87 | AURKA (0.41) | MAP2K7KDRTNNI3KMAPK14BRAF | |
| SCHEMBL5339167 | 0.85 | ALDH1A1 (0.42) | MAP2K7ALDH1A1KDRTNNI3KMAPK14 | |
| SCHEMBL5375763 | 0.82 | KDR (0.59) | KDRBRAF | |
| SCHEMBL5336916 | 0.82 | MAP2K7 (0.50) | MAP2K7KDRTNNI3K | |
| SCHEMBL5340417 | 0.80 | MAP2K7 (0.46) | MAP2K7ALDH1A1KDRTNNI3K | |
| SCHEMBL5332692 | 0.79 | MAP2K7 (0.46) | MAP2K7KDRTNNI3K | |
| SCHEMBL5416867 | 0.79 | MAP2K7 (0.50) | MAP2K7KDRTNNI3KMAPK14BRAF | |
| SCHEMBL5318628 | 0.77 | KDR (0.45) | MAP2K7KDRTNNI3KMAPK14BRAF | |
| SCHEMBL5451263 | 0.76 | MAP2K7 (0.47) | MAP2K7KDRTNNI3KMAPK14BRAF | |
| SCHEMBL5372666 | 0.74 | MAP2K7 (0.47) | MAP2K7ALDH1A1KDRTNNI3K |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076473-A2 | SUBSTITUTED PYRIMIDINYLOXY UREAS USEFUL AS INHIBITORS OF PROTEIN KINASES | KALYPSYS, INC. (US) | 2007-07-05 | — | — | WO | disclosed |