Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.51 |
| ▸ | FLT3 | P36888 | 11/20 | 0.51 |
| ▸ | KIT | P10721 | 11/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | LYN | P07948 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
| ▸ | FLT4 | P35916 | 1/20 | 0.44 |
| ▸ | BLK | P51451 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5329844 | 0.89 | KDR (0.63) | KDRFLT3KITPDGFRBABL1 | |
| SCHEMBL1380780 | 0.82 | FLT3 (0.58) | KDRFLT3KITPDGFRBLCK | |
| SCHEMBL4735877 | 0.81 | FLT3 (0.58) | KDRFLT3KITPDGFRBABL1 | |
| SCHEMBL4739605 | 0.76 | KDR (0.67) | KDRFLT3KITPDGFRBABL1 | |
| SCHEMBL1379853 | 0.74 | KDR (0.61) | KDRFLT3KITPDGFRBABL1 | |
| SCHEMBL419979 | 0.73 | KDR (0.70) | KDRFLT3KITPDGFRBABL1 | |
| SCHEMBL5336908 | 0.73 | KDR (0.59) | KDRFLT3KITLCKCSF1R | |
| SCHEMBL1381417 | 0.72 | KDR (0.66) | KDRFLT3KITPDGFRBLCK | |
| SCHEMBL4735746 | 0.72 | KDR (0.68) | KDRFLT3KITPDGFRBABL1 | |
| SCHEMBL4739508 | 0.72 | KDR (0.63) | KDRFLT3KITPDGFRBABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1850839-A2 | METHODS FOR TREATING OCULAR ANGIOGENESIS, RETINAL EDEMA, RETINAL ISCHEMIA, AND DIABETIC RETINOPATHY USING SELECTIVE RTK INHIBITORS | ALCON INC. (CH) | 2007-11-07 | — | — | EP | disclosed |
| WO-2006091801-A2 | METHODS FOR TREATING OCULAR ANGIOGENESIS, RETINAL EDEMA, RETINAL ISCHEMIA, AND DIABETIC RETINOPATHY USING SELECTIVE RTK INHIBITORS | ALCON, INC. (CH) | 2006-08-31 | — | — | WO | disclosed |