Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.59 |
| ▸ | KIT | P10721 | 6/20 | 0.59 |
| ▸ | FLT3 | P36888 | 5/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 2/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | TEK | Q02763 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1381023 | 0.83 | KDR (0.70) | KDRKITFLT3SMN1; SMN2POLB | |
| SCHEMBL5362753 | 0.81 | KDR (0.55) | KDRKITFLT3CSF1RMEN1 | |
| SCHEMBL4740220 | 0.78 | KDR (0.72) | KDRKITFLT3TP53TSHR | |
| SCHEMBL1383101 | 0.77 | KDR (0.67) | KDRKITFLT3CSF1RAURKA | |
| SCHEMBL1347812 | 0.74 | KIT (1.00) | KDRKITFLT3CSF1RAURKA | |
| SCHEMBL5333922 | 0.73 | KDR (0.51) | KDRKITFLT3SMN1; SMN2KDM4E | |
| SCHEMBL11106394 | 0.73 | RAB9A (0.85) | TP53TSHRSMN1; SMN2KDM4EPOLB | |
| SCHEMBL4737316 | 0.70 | KDR (0.68) | KDRKITFLT3CSF1RLCK | |
| SCHEMBL1379463 | 0.70 | KDR (0.71) | KDRKITFLT3CSF1RNPC1 | |
| SCHEMBL1383479 | 0.69 | KDR (0.70) | KDRKITFLT3CSF1RAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1850839-A2 | METHODS FOR TREATING OCULAR ANGIOGENESIS, RETINAL EDEMA, RETINAL ISCHEMIA, AND DIABETIC RETINOPATHY USING SELECTIVE RTK INHIBITORS | ALCON INC. (CH) | 2007-11-07 | — | — | EP | claimed |
| WO-2006091801-A2 | METHODS FOR TREATING OCULAR ANGIOGENESIS, RETINAL EDEMA, RETINAL ISCHEMIA, AND DIABETIC RETINOPATHY USING SELECTIVE RTK INHIBITORS | ALCON, INC. (CH) | 2006-08-31 | — | — | WO | claimed |