Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 9/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4247671 | 0.91 | CHEK2 (0.53) | PARP1GSK3BPDE10A | |
| SCHEMBL4243732 | 0.84 | HTT (0.56) | PARP1KDM4ERAB9ASMN1; SMN2PARP2 | |
| SCHEMBL4246128 | 0.83 | PDE10A (0.51) | PARP1NPC1RAB9APDE10ASMN1; SMN2 | |
| SCHEMBL4239153 | 0.82 | PARP1 (0.53) | PARP1PARP2 | |
| SCHEMBL4239167 | 0.81 | MAPT (0.50) | ALDH1A1KDM4EGSK3BNPC1RAB9A | |
| SCHEMBL4246220 | 0.81 | PARP1 (0.48) | PARP1PARP2 | |
| SCHEMBL4239376 | 0.78 | PARP1 (0.43) | PARP1CNR2PARP2 | |
| SCHEMBL4240726 | 0.77 | RAB9A (0.63) | PARP1ALDH1A1KDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL4247673 | 0.77 | CHEK2 (0.49) | PARP1ALDH1A1KDM4EGSK3BPDE10A | |
| SCHEMBL4243580 | 0.77 | PARP1 (0.62) | PARP1PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863771-A2 | BENZAZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE AS B-SECRETASE INHIBITORS | Transtech Pharma, Inc. (US) | 2007-12-12 | — | — | EP | claimed |
| WO-2006099379-A2 | BENZAZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE AS B-SECRETASE INHIBITORS | TRANSTECH PHARMA, INC. (US) | 2006-09-21 | — | — | WO | claimed |