Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.54 |
| ▸ | HPGD | P15428 | 6/20 | 0.54 |
| ▸ | USP2 | O75604 | 3/20 | 0.54 |
| ▸ | CASP1 | P29466 | 3/20 | 0.54 |
| ▸ | CASP7 | P55210 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.54 |
| ▸ | GLA | P06280 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 5/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5330819 | 0.93 | KDM4E (0.57) | ALDH1A1KDM4EHPGDUSP2CASP1 | |
| SCHEMBL5310139 | 0.90 | ALDH1A1 (0.57) | ALDH1A1KDM4EHPGDUSP2CASP1 | |
| SCHEMBL5337018 | 0.86 | ALDH1A1 (0.53) | ALDH1A1KDM4EHPGDUSP2CASP1 | |
| SCHEMBL3324948 | 0.86 | KDM4E (0.50) | ALDH1A1KDM4EHPGDUSP2CASP1 | |
| SCHEMBL5331923 | 0.85 | ALDH1A1 (0.54) | ALDH1A1KDM4EHPGDUSP2CASP1 | |
| SCHEMBL13096492 | 0.85 | ALDH1A1 (0.53) | ALDH1A1KDM4EHPGDUSP2CASP1 | |
| SCHEMBL3329941 | 0.84 | KDM4E (0.56) | ALDH1A1KDM4EHPGDUSP2CASP1 | |
| SCHEMBL9925963 | 0.84 | ALDH1A1 (0.61) | ALDH1A1KDM4EHPGDUSP2CASP1 | |
| SCHEMBL5334064 | 0.84 | KDM4E (0.58) | ALDH1A1KDM4EHPGDUSP2CASP1 | |
| SCHEMBL3323108 | 0.82 | ALDH1A1 (0.51) | ALDH1A1KDM4EHPGDUSP2CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070112015-A1 | Substituted dihydropyridines and methods of use | CHEMOCENTRYX, INC. (US) | 2007-05-17 | — | — | US | disclosed |
| WO-2007051062-A2 | SUBSTITUTED DIHYDROPYRIDINES AND METHODS OF USE | CHEMOCENTRYX, INC. (US) | 2007-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070112015-A1 | Substituted dihydropyridines and methods of use | C3AR1, C5AR1, C5AR2 | ALDH1A1 1488/4885KDM4E 4033/4885HPGD 675/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.