Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 18/20 | 0.52 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | KDM6B | O15054 | 1/20 | 0.44 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.44 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5306464 | 0.89 | HCAR2 (0.55) | HCAR2 | |
| SCHEMBL5300871 | 0.88 | KDM4E (0.48) | HCAR2HDAC1HDAC6 | |
| SCHEMBL5062205 | 0.87 | HCAR2 (0.64) | HCAR2CYP2C8CYP2C9KDM6BKDM4D | |
| SCHEMBL5298682 | 0.84 | HCAR2 (0.54) | HCAR2CYP2C8CYP2C9KDM6BKDM4D | |
| SCHEMBL5293834 | 0.83 | HCAR2 (0.54) | HCAR2CYP2C8CYP2C9KDM6BKDM4D | |
| SCHEMBL5301209 | 0.81 | HCAR2 (0.59) | HCAR2HDAC1 | |
| SCHEMBL5334252 | 0.80 | HCAR2 (0.49) | HCAR2CYP2C8CYP2C9HDAC1HDAC6 | |
| SCHEMBL5328705 | 0.80 | KDM6B (0.56) | HCAR2CYP2C8CYP2C9KDM6BKDM4D | |
| SCHEMBL5300950 | 0.79 | HCAR2 (0.50) | HCAR2HDAC1HDAC6 | |
| SCHEMBL14609697 | 0.79 | HCAR2 (0.58) | HCAR2CYP2C8CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007015744-A1 | DISUBSTITUTED THIENYL COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2007-02-08 | — | — | WO | claimed |
| WO-2007015744-A1 | DISUBSTITUTED THIENYL COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2007-02-08 | — | — | WO | disclosed |