Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | ESR1 | P03372 | 1/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 2/20 | 0.48 |
| ▸ | MAOB | P27338 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | DRD5 | P21918 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2103706 | 0.90 | KMT2A (0.64) | KMT2AMEN1ESR1ESR2L3MBTL1 | |
| SCHEMBL29325467 | 0.79 | ESR1 (0.48) | KMT2AMEN1ALDH1A1ESR1ESR2 | |
| SCHEMBL30721536 | 0.79 | ESR1 (0.55) | KMT2AMEN1ESR1ESR2L3MBTL1 | |
| SCHEMBL30721539 | 0.79 | ESR1 (0.55) | KMT2AMEN1ESR1ESR2L3MBTL1 | |
| SCHEMBL2060640 | 0.77 | ESR2 (0.54) | ESR1ESR2L3MBTL1CYP2D6HRH3 | |
| SCHEMBL1266336 | 0.77 | ESR1 (0.49) | KMT2AMEN1ALDH1A1ESR1ESR2 | |
| SCHEMBL17227611 | 0.76 | KMT2A (0.62) | KMT2AMEN1L3MBTL1SMN1; SMN2MAOA | |
| SCHEMBL31629349 | 0.76 | ALDH1A1 (0.44) | KMT2AMEN1ALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL29325471 | 0.76 | GRIN1 (0.50) | ALDH1A1ESR1ESR2CYP1A2CYP3A4 | |
| SCHEMBL3007964 | 0.75 | KMT2A (0.66) | KMT2AMEN1L3MBTL1SMN1; SMN2MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833473-A2 | 5HT2C RECEPTOR MODULATOR COMPOSITIONS AND METHODS OF USE | Arena Pharmaceuticals, Inc. (US) | 2007-09-19 | — | — | EP | claimed |
| WO-2006071740-A2 | 5HT2C RECEPTOR MODULATOR COMPOSITIONS AND METHODS OF USE | ARENA PHARMACEUTICALS, INC. (US) | 2006-07-06 | — | — | WO | claimed |