Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 6/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.59 |
| ▸ | HPGD | P15428 | 6/20 | 0.59 |
| ▸ | CASP1 | P29466 | 5/20 | 0.59 |
| ▸ | USP2 | O75604 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | CASP7 | P55210 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5475490 | 0.92 | GAA (0.61) | GAAALDH1A1KDM4EHPGDCASP1 | |
| SCHEMBL5333650 | 0.89 | GAA (0.72) | GAAALDH1A1KDM4EHPGDCASP1 | |
| SCHEMBL5340474 | 0.87 | ALDH1A1 (0.71) | GAAALDH1A1KDM4EHPGDCASP1 | |
| SCHEMBL5475499 | 0.85 | ALDH1A1 (0.53) | GAAALDH1A1KDM4EHPGDCASP1 | |
| SCHEMBL5338987 | 0.84 | GAA (0.73) | GAAALDH1A1KDM4EHPGDCASP1 | |
| SCHEMBL5335394 | 0.84 | GAA (1.00) | GAAALDH1A1KDM4EHPGDCASP1 | |
| SCHEMBL5331132 | 0.83 | GAA (0.72) | GAAALDH1A1KDM4EHPGDCASP1 | |
| SCHEMBL5333414 | 0.83 | GAA (0.72) | GAAALDH1A1KDM4EHPGDCASP1 | |
| SCHEMBL5497825 | 0.82 | GAA (0.71) | GAAALDH1A1KDM4EHPGDCASP1 | |
| SCHEMBL5332462 | 0.82 | ALDH1A1 (0.84) | GAAALDH1A1KDM4EHPGDCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070112015-A1 | Substituted dihydropyridines and methods of use | CHEMOCENTRYX, INC. (US) | 2007-05-17 | — | — | US | disclosed |
| WO-2007051062-A2 | SUBSTITUTED DIHYDROPYRIDINES AND METHODS OF USE | CHEMOCENTRYX, INC. (US) | 2007-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070112015-A1 | Substituted dihydropyridines and methods of use | C3AR1, C5AR1, C5AR2 | GAA 3421/4885ALDH1A1 1488/4885KDM4E 4033/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.