Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 4/20 | 0.51 |
| ▸ | CA1 | P00915 | 3/20 | 0.51 |
| ▸ | CA9 | Q16790 | 2/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CHRNA7 | P36544 | 6/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 9/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | CA5A | P35218 | 1/20 | 0.47 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2465664 | 0.89 | CHRNA7 (0.56) | CA2CA1CA9CA12CHRNA7 | |
| SCHEMBL2463842 | 0.81 | CA1 (0.59) | CA2CA1CA9CA12CHRNA7 | |
| SCHEMBL347479 | 0.81 | CA1 (0.59) | CA2CA1CA9CA12CHRNA7 | |
| SCHEMBL17917307 | 0.75 | CHRNA7 (0.56) | CA2CA1CA9CA12CHRNA7 | |
| SCHEMBL5314130 | 0.74 | CA9 (0.62) | CA2CA1CA9CA12CHRNA7 | |
| SCHEMBL5314069 | 0.73 | PTGS2 (0.69) | CA2CA1CA9CA12PTGS2 | |
| SCHEMBL5311859 | 0.73 | PTGS2 (0.69) | CA2CA1CA9CA12PTGS2 | |
| Apricoxib SCHEMBL3435344 | 0.73 | CA1 (0.60) | CA2CA1CA9CA12CHRNA7 | |
| Apricoxib SCHEMBL346028 | 0.73 | CA1 (0.60) | CA2CA1CA9CA12CHRNA7 | |
| SCHEMBL5309213 | 0.73 | CA1 (0.45) | CA2CA1CA9CA12CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799823-B1 | 1,2-Diphenylpyrrole derivatives, their preparation and their therapeutic uses | DAIICHI SANKYO CO LTD (JP) | 2007-10-31 | — | — | EP | disclosed |
| US-RE39420-E1 | 1,2-Diphenylpyrrole derivatives, their preparation and their therapeutic uses | SANKYO COMPANY, LIMITED (JP) | 2006-12-05 | — | — | US | disclosed |
| US-5908858-A | OSTEOPOROSIS; LEUKOTRIENE INHIBITOR | SANKYO COMPANY, LIMITED (JP) | 1999-06-01 | — | — | US | disclosed |
| EP-0799823-A1 | 1,2-Diphenylpyrrole derivatives, their preparation and their therapeutic uses | SANKYO COMPANY LIMITED (JP) | 1997-10-08 | — | — | EP | disclosed |